Pan Ting, Li Qingrong
School of Life Sciences and Laboratory Medicine, Kunming Medical University, Kunming, China.
J Bacteriol. 2025 May 22;207(5):e0001225. doi: 10.1128/jb.00012-25. Epub 2025 Apr 29.
is a clinically important pathogenic bacteria that poses a serious threat to human health. In particular, the emergence of hypervirulent and multidrug-resistant has posed great challenges in clinical anti-infective therapy. In the genome, mobile genetic elements (MGEs), such as plasmids, prophages, transposons, and insertion sequences, enhance bacterial viability and adaptation by mediating the horizontal transfer of virulence genes, antibiotic resistance genes, and other adaptive genes. This paper reviews the types and characteristics of the main MGEs in , focusing on their effects on bacterial virulence and antibiotic resistance, with the aim of providing clues for developing infection control measures and new antibacterial drugs.
是一种临床上重要的病原菌,对人类健康构成严重威胁。特别是,高毒力和多重耐药性的出现给临床抗感染治疗带来了巨大挑战。在基因组中,移动遗传元件(MGEs),如质粒、原噬菌体、转座子和插入序列,通过介导毒力基因、抗生素抗性基因和其他适应性基因的水平转移来增强细菌的生存能力和适应性。本文综述了中的主要MGEs的类型和特征,重点关注它们对细菌毒力和抗生素抗性的影响,旨在为制定感染控制措施和新型抗菌药物提供线索。