Wang Sumei, He Shasha, Hu Xiao, Liu Fusheng, Fang Xiaolei, Huang Po
Dongfang Hospital, Beijing University of Traditional Chinese Medicine, Beijing, China.
Beijing Hospital of Traditional Chinese Medicine, Affiliated with Capital Medical University, Beijing, China.
Inflamm Res. 2025 Apr 29;74(1):76. doi: 10.1007/s00011-025-02037-0.
Sepsis has emerged as the most pressing health concerns globally in emergency and intensive care unit. Sepsis-Induced Cardiomyopathy (SIC) represents an acute cardiac insufficiency syndrome secondary to sepsis, characterized by a high incidence and a significant increase in mortality among sepsis patients. To date, no specific treatment exists for this condition. In recent years, mounting evidence has indicated that Nrf2 plays a critical protective role in SIC and may represent a potential therapeutic target.
Pubmed database literature was searched for studies pertaining to the role of Nrf2 in sepsis, from the inception of the database to October 1, 2024. Biorender software was performed to draw the corresponding mechanism diagram.
Using the keywords "Nrf2 and Sepsis", we initially identified 454 articles. To refine our search, we employed "Nrf2 and Sepsis and Cardiac" as keywords, yielding 63 articles. Upon reviewing the full texts, we selected 26 studies for inclusion in our review. Nrf2 is implicated in various protective aspects against cardiomyocyte injury stemming from sepsis, including its inhibitory effects on inflammation, apoptosis, mitochondrial dysfunction, pyroptosis, and ferroptosis. 23 natural compounds under investigation for this application were identified.
The Nrf2-mediated signaling pathway plays a critical role in sepsis-induced myocardial injury. Given the complex, systemic, and multifactorial nature of sepsis, these natural compounds should be regarded as adjunctive therapeutic options for scholarly investigation rather than standalone therapeutic interventions. Substantial future research will still be required to validate their clinical efficacy and mechanistic roles.
脓毒症已成为全球急诊和重症监护病房中最紧迫的健康问题。脓毒症诱导的心肌病（SIC）是一种继发于脓毒症的急性心脏功能不全综合征，其特征是脓毒症患者的发病率高且死亡率显著增加。迄今为止，针对这种病症尚无特效治疗方法。近年来，越来越多的证据表明，Nrf2在SIC中发挥着关键的保护作用，可能是一个潜在的治疗靶点。
检索了PubMed数据库从建库至2024年10月1日有关Nrf2在脓毒症中作用的研究。使用Biorender软件绘制相应的机制图。
使用关键词“Nrf2与脓毒症”，我们初步检索到454篇文章。为了优化检索，我们使用“Nrf2与脓毒症与心脏”作为关键词，得到63篇文章。在阅读全文后，我们选择了26项研究纳入本综述。Nrf2在抵御脓毒症引起的心肌细胞损伤的各个保护方面都有涉及，包括对炎症、凋亡、线粒体功能障碍、焦亡和铁死亡的抑制作用。确定了23种正在研究用于此用途的天然化合物。
Nrf2介导的信号通路在脓毒症诱导的心肌损伤中起关键作用。鉴于脓毒症的复杂性、系统性和多因素性质，这些天然化合物应被视为学术研究的辅助治疗选择，而非独立的治疗干预措施。未来仍需要大量研究来验证它们的临床疗效和作用机制。
