• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

迁移小体标志物表皮生长因子结构域特异性β-N-乙酰氨基葡萄糖转移酶：泛癌血管生成生物标志物以及circ_0058189/miR-130a-3p/EOGT轴在肝细胞癌进展和索拉非尼耐药中的潜在作用

Migrasome Marker Epidermal Growth Factor Domain-Specific -GlcNAc Transferase: Pan-Cancer Angiogenesis Biomarker and the Potential Role of circ_0058189/miR-130a-3p/EOGT Axis in Hepatocellular Carcinoma Progression and Sorafenib Resistance.

作者信息

Yu Zhe, Luo Jing, An Wen, Wei Herui, Li Mengqi, He Lingling, Xiao Fan, Wei Hongshan

机构信息

Department of Gastroenterology, Peking University Ditan Teaching Hospital, Beijing 100015, China.

Department of Cancer Center, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.

出版信息

Biomedicines. 2025 Mar 22;13(4):773. doi: 10.3390/biomedicines13040773.

DOI:10.3390/biomedicines13040773
PMID:40299340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12024942/
Abstract

: The EGF domain-specific O-GlcNAc transferase (EOGT), a migrasome marker, plays emerging roles in cancer biology through O-GlcNAcylation modifications, yet its pan-cancer functions and therapeutic implications remain underexplored. This study aimed to systematically characterize EOGT's oncogenic mechanisms across malignancies, with particular focus on hepatocellular carcinoma (HCC) progression and sorafenib resistance. : Multi-omics analysis integrated TCGA/GTEx data from 33 cancer types with spatial/single-cell transcriptomics and 10 HCC cohorts. Functional validation employed Huh7 cell models with modulation, RNA sequencing, and ceRNA network construction. Drug sensitivity analysis leveraged GDSC/CTRP/PRISM databases, while immune microenvironment assessment utilized ESTIMATE/TIMER algorithms. : showed cancer-specific dysregulation, marked by significant upregulation in HCC correlating with advanced stages and poor survival. Pan-cancer analysis revealed 's association with genomic instability, tumor stemness, and angiogenesis. Experimental validation demonstrated EOGT's promotion of HCC proliferation and migration. A novel exosomal circ_0058189/miR-130a-3p/EOGT axis was identified, showing that circ_0058189 was upregulated in HCC tissues, plasma samples and exosomes of sorafenib-resistant cells. : This study establishes EOGT as a pan-cancer angiogenesis biomarker, while elucidating its role in therapeutic resistance via exosomal circRNA-mediated regulation, providing mechanistic insights for targeted intervention strategies.

摘要

表皮生长因子（EGF）结构域特异性O-连接N-乙酰葡糖胺转移酶（EOGT）是一种迁移体标志物，通过O-连接N-乙酰葡糖胺化修饰在癌症生物学中发挥着新出现的作用，但其在泛癌中的功能及治疗意义仍未得到充分探索。本研究旨在系统地阐明EOGT在各种恶性肿瘤中的致癌机制，尤其关注肝细胞癌（HCC）的进展及对索拉非尼的耐药性。：多组学分析整合了来自33种癌症类型的TCGA/GTEx数据以及空间/单细胞转录组学数据和10个HCC队列的数据。功能验证采用对Huh7细胞模型进行调控、RNA测序及构建ceRNA网络的方法。药物敏感性分析利用了GDSC/CTRP/PRISM数据库，而免疫微环境评估则采用了ESTIMATE/TIMER算法。：结果显示癌症特异性失调，其特征为在HCC中显著上调，且与晚期阶段及不良生存相关。泛癌分析揭示了其与基因组不稳定性、肿瘤干性及血管生成的关联。实验验证表明EOGT可促进HCC的增殖和迁移。还鉴定出了一种新的外泌体circ_0058189/miR-130a-3p/EOGT轴，结果显示circ_0058189在HCC组织、血浆样本及索拉非尼耐药细胞的外泌体中表达上调。：本研究确立了EOGT作为一种泛癌血管生成生物标志物的地位，同时阐明了其通过外泌体circRNA介导的调控在治疗耐药中的作用，为靶向干预策略提供了机制性见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46c0/12024942/e3a25d642527/biomedicines-13-00773-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46c0/12024942/96afaa58a1f6/biomedicines-13-00773-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46c0/12024942/534d8190a996/biomedicines-13-00773-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46c0/12024942/f004b4e7601b/biomedicines-13-00773-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46c0/12024942/cc107864d334/biomedicines-13-00773-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46c0/12024942/1365b2d72e66/biomedicines-13-00773-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46c0/12024942/a54e6811572b/biomedicines-13-00773-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46c0/12024942/52f12e22e5bb/biomedicines-13-00773-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46c0/12024942/f2b5ef0ed8dc/biomedicines-13-00773-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46c0/12024942/e3a25d642527/biomedicines-13-00773-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46c0/12024942/96afaa58a1f6/biomedicines-13-00773-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46c0/12024942/534d8190a996/biomedicines-13-00773-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46c0/12024942/f004b4e7601b/biomedicines-13-00773-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46c0/12024942/cc107864d334/biomedicines-13-00773-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46c0/12024942/1365b2d72e66/biomedicines-13-00773-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46c0/12024942/a54e6811572b/biomedicines-13-00773-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46c0/12024942/52f12e22e5bb/biomedicines-13-00773-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46c0/12024942/f2b5ef0ed8dc/biomedicines-13-00773-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46c0/12024942/e3a25d642527/biomedicines-13-00773-g009.jpg

相似文献

1
Migrasome Marker Epidermal Growth Factor Domain-Specific -GlcNAc Transferase: Pan-Cancer Angiogenesis Biomarker and the Potential Role of circ_0058189/miR-130a-3p/EOGT Axis in Hepatocellular Carcinoma Progression and Sorafenib Resistance.迁移小体标志物表皮生长因子结构域特异性β-N-乙酰氨基葡萄糖转移酶：泛癌血管生成生物标志物以及circ_0058189/miR-130a-3p/EOGT轴在肝细胞癌进展和索拉非尼耐药中的潜在作用
Biomedicines. 2025 Mar 22;13(4):773. doi: 10.3390/biomedicines13040773.
2
EOGT knockdown promotes ferroptosis and inhibits hepatocellular carcinoma proliferation by regulating SLC7A11 via HEY1.EOGT基因敲低通过HEY1调节SLC7A11，促进铁死亡并抑制肝癌细胞增殖。
Cell Signal. 2025 Aug;132:111772. doi: 10.1016/j.cellsig.2025.111772. Epub 2025 Mar 26.
3
EOGT Correlated With Immune Infiltration: A Candidate Prognostic Biomarker for Hepatocellular Carcinoma.EOGT 与免疫浸润相关：肝细胞癌的候选预后生物标志物。
Front Immunol. 2022 Jan 5;12:780509. doi: 10.3389/fimmu.2021.780509. eCollection 2021.
4
Circ_0001944 Targets the miR-1292-5p/FBLN2 Axis to Facilitate Sorafenib Resistance in Hepatocellular Carcinoma by Impeding Ferroptosis.Circ_0001944靶向miR-1292-5p/FBLN2轴，通过抑制铁死亡促进肝细胞癌对索拉非尼的耐药性。
Immunotargets Ther. 2024 Nov 26;13:643-659. doi: 10.2147/ITT.S463556. eCollection 2024.
5
Exosomal circ_0032704 confers sorafenib resistance to hepatocellular carcinoma and contributes to cancer malignant progression by modulating the miR-514a-3p/PD-L1 pathway.外泌体circ_0032704赋予肝癌对索拉非尼的抗性，并通过调节miR-514a-3p/PD-L1途径促进癌症恶性进展。
Ann Gastroenterol Surg. 2024 Jan 23;8(3):507-520. doi: 10.1002/ags3.12772. eCollection 2024 May.
6
Exosome-transmitted circ_002136 promotes hepatocellular carcinoma progression by miR-19a-3p/RAB1A pathway.外泌体传递的 circ_002136 通过 miR-19a-3p/RAB1A 通路促进肝癌进展。
BMC Cancer. 2022 Dec 7;22(1):1284. doi: 10.1186/s12885-022-10367-z.
7
Impaired O-linked N-acetylglucosaminylation in the endoplasmic reticulum by mutated epidermal growth factor (EGF) domain-specific O-linked N-acetylglucosamine transferase found in Adams-Oliver syndrome.在亚当斯-奥利弗综合征中发现的突变型表皮生长因子（EGF）结构域特异性O-连接N-乙酰葡糖胺转移酶导致内质网中O-连接N-乙酰葡糖胺糖基化受损。
J Biol Chem. 2015 Jan 23;290(4):2137-49. doi: 10.1074/jbc.M114.598821. Epub 2014 Dec 8.
8
Circ_RBM23 knockdown suppresses chemoresistance, proliferation, migration and invasion of sorafenib-resistant HCC cells through miR-338-3p/RAB1B axis.环状 RNA RBM23 敲低通过 miR-338-3p/RAB1B 轴抑制索拉非尼耐药 HCC 细胞的化疗耐药性、增殖、迁移和侵袭。
Pathol Res Pract. 2023 May;245:154435. doi: 10.1016/j.prp.2023.154435. Epub 2023 Apr 5.
9
Golgi phosphoprotein 3 promotes angiogenesis and sorafenib resistance in hepatocellular carcinoma via upregulating exosomal miR-494-3p.高尔基体磷蛋白3通过上调外泌体miR-494-3p促进肝细胞癌血管生成和索拉非尼耐药。
Cancer Cell Int. 2022 Jan 24;22(1):35. doi: 10.1186/s12935-022-02462-9.
10
Bioinformatic analysis shows the correlation of hsa_circ_0006220-miR-221/222-3p-ESR1/KDR axis with sorafenib resistance of hepatocellular carcinoma.生物信息学分析显示hsa_circ_0006220-miR-221/222-3p-ESR1/KDR轴与肝细胞癌索拉非尼耐药性的相关性。
Noncoding RNA Res. 2023 Nov 2;9(1):55-65. doi: 10.1016/j.ncrna.2023.11.001. eCollection 2024 Mar.

本文引用的文献

1
Circular RNA in cancer.环状 RNA 与癌症。
Nat Rev Cancer. 2024 Sep;24(9):597-613. doi: 10.1038/s41568-024-00721-7. Epub 2024 Jul 29.
2
Sangerbox: A comprehensive, interaction-friendly clinical bioinformatics analysis platform.Sangerbox：一个全面的、用户交互友好的临床生物信息学分析平台。
Imeta. 2022 Jul 8;1(3):e36. doi: 10.1002/imt2.36. eCollection 2022 Sep.
3
CD151-enriched migrasomes mediate hepatocellular carcinoma invasion by conditioning cancer cells and promoting angiogenesis.富含 CD151 的迁移小体通过调节癌细胞和促进血管生成来介导肝细胞癌侵袭。
J Exp Clin Cancer Res. 2024 Jun 6;43(1):160. doi: 10.1186/s13046-024-03082-z.
4
Novel insights into the roles of migrasome in cancer.对迁移体在癌症中作用的新见解。
Discov Oncol. 2024 May 15;15(1):166. doi: 10.1007/s12672-024-00942-0.
5
TGF-β signaling in health, disease, and therapeutics.TGF-β 信号在健康、疾病和治疗中的作用。
Signal Transduct Target Ther. 2024 Mar 22;9(1):61. doi: 10.1038/s41392-024-01764-w.
6
TGF-β, EMT, and resistance to anti-cancer treatment.转化生长因子-β（TGF-β）、上皮间质转化（EMT）和抗癌治疗耐药性。
Semin Cancer Biol. 2023 Dec;97:1-11. doi: 10.1016/j.semcancer.2023.10.004. Epub 2023 Nov 8.
7
IHGA: An interactive web server for large-scale and comprehensive discovery of genes of interest in hepatocellular carcinoma.IHGA：一个用于大规模全面发现肝细胞癌中感兴趣基因的交互式网络服务器。
Comput Struct Biotechnol J. 2023 Aug 6;21:3987-3998. doi: 10.1016/j.csbj.2023.08.003. eCollection 2023.
8
O-GlcNAcylation in cancer development and immunotherapy.O-糖基化在癌症发展和免疫治疗中的作用。
Cancer Lett. 2023 Jul 10;566:216258. doi: 10.1016/j.canlet.2023.216258. Epub 2023 Jun 4.
9
Roles of TGF-β signals in tumor microenvironment via regulation of the formation and plasticity of vascular system.转化生长因子-β信号通过调节血管系统的形成和可塑性在肿瘤微环境中的作用。
Semin Cancer Biol. 2023 Jul;92:130-138. doi: 10.1016/j.semcancer.2023.04.007. Epub 2023 Apr 15.
10
Exosomal circular RNAs: A chief culprit in cancer chemotherapy resistance.外泌体环状 RNA：癌症化疗耐药的罪魁祸首。
Drug Resist Updat. 2023 Mar;67:100937. doi: 10.1016/j.drup.2023.100937. Epub 2023 Feb 2.