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采用条状移植和异种真皮基质联合方法进行下颌种植体周围角化黏膜增量:病例系列

A Combined Approach Using Strip Grafts and Xenogenic Dermal Matrix for Peri-Implant Keratinized Mucosa Augmentation in the Mandible: A Case Series.

作者信息

Li Xinda, Palkovics Dániel, Windisch Péter, Perić Kačarević Željka, Horváth Attila

机构信息

Department of Periodontology, Semmelweis University, 1088 Budapest, Hungary.

出版信息

Biomedicines. 2025 Mar 27;13(4):806. doi: 10.3390/biomedicines13040806.

Abstract

Ensuring a minimum peri-implant keratinized mucosa width (PIKM-W) is critical for maintaining dental implant health, as inadequate PIKM-W is associated with increased risks of plaque accumulation, mucosal inflammation, and peri-implantitis. While epithelialized connective tissue grafts (ECTGs) are considered the gold standard for soft tissue augmentation, they often lead to significant patient morbidity. Xenogeneic dermal matrices (XDMs) offer a less invasive alternative, but are prone to shrinkage, particularly in the mandible. The aim of this study was to evaluate a new surgical method to overcome these limitations with the combination of a narrow band of ECTG (autogenous strip graft, ASG) and an XDM to augment the PIKM-W in the posterior mandible. Twelve patients with a PIKM-W of less than 2 mm in the mandible underwent peri-implant soft tissue augmentation using this combined approach. Changes in the PIKM-W were measured preoperatively; immediately postoperatively; and at 1, 3, 6, 9, and 12 months. Graft remodeling (shrinkage or contraction) and PIKM thickness (PIKM-T) were also evaluated over time. Preoperatively, the mean PIKM-W was 0.39 ± 0.40 mm and the PIKM-T was 1.36 ± 0.43 mm. At 6 months, the mean PIKM-W was 4.93 ± 0.98 mm and the PIKM-T was 2.88 ± 0.80 mm, with shrinkage of 39.2 ± 14.1%. By 12 months, the mean PIKM-W stabilized at 4.58 ± 1.28 mm and the PIKM-T stabilized at 2.83 ± 0.65 mm, with shrinkage of 42.2% ± 16.8%. There were statistically significant differences in clinical parameters between the baseline and 6 and 12 months ( < 0.05). This technique demonstrated the potential for stable augmentation of PIKM-W and PIKM-T over time, with manageable shrinkage. However, further studies with larger sample sizes are needed to confirm its clinical efficacy as an alternative for mandibular keratinized mucosa augmentation around implants.

摘要

确保种植体周围角化黏膜宽度(PIKM-W)达到最小值对于维持牙种植体健康至关重要,因为PIKM-W不足与菌斑堆积、黏膜炎症及种植体周围炎风险增加相关。虽然上皮化结缔组织移植(ECTG)被认为是软组织增量的金标准,但它们常常导致患者出现明显的发病率。异种真皮基质(XDM)提供了一种侵入性较小的替代方法,但容易收缩,尤其是在下颌骨。本研究的目的是评估一种新的手术方法,通过结合窄带ECTG(自体条带移植,ASG)和XDM来克服这些局限性,以增加下颌骨后部的PIKM-W。12例下颌骨PIKM-W小于2mm的患者采用这种联合方法进行种植体周围软组织增量。在术前、术后即刻以及术后1、3、6、9和12个月测量PIKM-W的变化。还随时间评估移植物重塑(收缩或挛缩)和PIKM厚度(PIKM-T)。术前,平均PIKM-W为0.39±0.40mm,PIKM-T为1.36±0.43mm。在6个月时,平均PIKM-W为4.93±0.98mm,PIKM-T为2.88±0.80mm,收缩率为39.2±14.1%。到12个月时,平均PIKM-W稳定在4.58±1.28mm,PIKM-T稳定在2.83±0.65mm,收缩率为42.2%±16.8%。基线与6个月和12个月时的临床参数存在统计学显著差异(<0.05)。该技术显示出随着时间的推移稳定增加PIKM-W和PIKM-T的潜力,且收缩可控。然而,需要更大样本量的进一步研究来证实其作为种植体周围下颌角化黏膜增量替代方法的临床疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6328/12025105/a6ad57964a0c/biomedicines-13-00806-g001.jpg

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