Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Front Neuroendocrinol. 2020 Jul;58:100852. doi: 10.1016/j.yfrne.2020.100852. Epub 2020 Jun 15.
The tumour microenvironment (TME) includes a variety of non-neoplastic cells and non-cellular elements such as cytokines, growth factors and enzymes surrounding tumour cells. The TME emerged as a key modulator of tumour initiation, progression and invasion, with extensive data available in many cancers, but little is known in pituitary tumours. However, the understanding of the TME of pituitary tumours has advanced thanks to active research in this field over the last decade. Different immune and stromal cell subpopulations, and several cytokines, growth factors and matrix remodelling enzymes, have been characterised in pituitary tumours. Studying the TME in pituitary tumours may lead to a better understanding of tumourigenic mechanisms, identification of biomarkers useful to predict aggressive disease, and development of novel therapies. This review summarises the current knowledge on the different TME cellular/non-cellular elements in pituitary tumours and provides an overview of their role in tumourigenesis, biological behaviour and clinical outcomes.
肿瘤微环境（TME）包括肿瘤细胞周围的多种非肿瘤细胞和非细胞成分，如细胞因子、生长因子和酶。TME 已成为肿瘤发生、进展和侵袭的关键调节剂，在许多癌症中有大量数据，但在垂体肿瘤中知之甚少。然而，由于过去十年在该领域的积极研究，对垂体肿瘤 TME 的理解已经取得了进展。不同的免疫和基质细胞亚群以及几种细胞因子、生长因子和基质重塑酶已在垂体肿瘤中得到描述。研究垂体肿瘤的 TME 可能有助于更好地了解致瘤机制，确定有助于预测侵袭性疾病的生物标志物，并开发新的治疗方法。这篇综述总结了目前关于垂体肿瘤中不同的 TME 细胞/非细胞成分的知识，并概述了它们在肿瘤发生、生物学行为和临床结果中的作用。
