Wang Shenghang, Yang Jiancheng, Wei Yunpeng, Cai Chao, Chen Shuai, Wu Youde, Li Xiao, Sun Lilei, Li Xianglin, Gong Ming, Zhou Jianhua, Hu Yawei, Zhang Wang, Guo Zengfeng, Liao Jiacheng, Luo Chunling, Bai Xiaosu, Luo Xinle, Duan Liming, Huyan Ting, Yang Zhouqi, Wei Min, Fang Yanwen, Zhang Hao, Shang Peng
Department of Spine Surgery, People's Hospital of Longhua, Shenzhen, China.
Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, China.
PLoS One. 2025 Apr 29;20(4):e0314199. doi: 10.1371/journal.pone.0314199. eCollection 2025.
Postmenopausal osteoporosis (PMOP) is the most common type of osteoporosis. Numerous studies have shown that static magnetic fields (SMFs) can inhibit bone loss by regulating bone remodeling. However, there are currently no clinical studies on the treatment of osteoporosis with SMFs. This study aims to investigate the clinical therapeutic effects of moderate static magnetic fields (MMFs) on PMOP.
In this paper, we constructed MMF device using neodymium-iron-boron (NdFeB) materials. At the animal level, the effect of MMF exposure for 8 weeks on estrogen deficiency-induced bone loss was investigated by evaluating bone microstructure, mechanical properties, and bone conversion using ovariectomized (OVX) mice. Clinically, a single-blind randomized controlled study in patients with PMOP was designed. PMOP patients aged 55-70 years were recruited and randomized into the control and MMF treatment groups. Clinical assessments of bone mineral density (BMD), bone turnover markers (BTMs) and VAS scores were performed at baseline and day 90, respectively.
The results showed that MMF exposure significantly improved BMD, bone mineral content (BMC), bone microarchitecture and bone strength in OVX mice. For bone turnover, MMF increased the number of osteoblasts on the bone surface of OVX mice as well as the level of serum bone formation marker P1NP, while decreasing the number of osteoclasts and the level of serum bone resorption marker β-CTX. The clinical trial's results showed that MMF treatment had a positive effect on the improvement of BMD in the lumbar spine and increased serum P1NP levels while decreased β-CTX levels. In addition, MMF treatment decreased participants' VAS scores for low back pain.
The results of both animal and clinical studies demonstrated that MMF treatment improved bone turnover and have a positive effect on BMD improvement, as well as alleviated low back pain in PMOP patients. This study will promote the translational research and clinical application of SMF treatment for osteoporosis.
Intervention study of moderate static magnetic field on osteoporosis and iron metabolism in postmenopausal women, ChiCTR2100048604.
绝经后骨质疏松症（PMOP）是最常见的骨质疏松类型。大量研究表明，静磁场（SMF）可通过调节骨重塑来抑制骨质流失。然而，目前尚无关于静磁场治疗骨质疏松症的临床研究。本研究旨在探讨中度静磁场（MMF）对PMOP的临床治疗效果。
在本文中，我们使用钕铁硼（NdFeB）材料构建了MMF装置。在动物层面，通过对去卵巢（OVX）小鼠的骨微结构、力学性能和骨转换进行评估，研究了MMF暴露8周对雌激素缺乏引起的骨质流失的影响。在临床方面，设计了一项针对PMOP患者的单盲随机对照研究。招募年龄在55 - 70岁的PMOP患者，并将其随机分为对照组和MMF治疗组。分别在基线和第90天对骨密度（BMD）、骨转换标志物（BTM）和视觉模拟评分（VAS）进行临床评估。
结果显示，MMF暴露显著改善了OVX小鼠的骨密度、骨矿物质含量（BMC）、骨微结构和骨强度。对于骨转换，MMF增加了OVX小鼠骨表面的成骨细胞数量以及血清骨形成标志物P1NP的水平，同时减少了破骨细胞数量和血清骨吸收标志物β-CTX的水平。临床试验结果表明，MMF治疗对改善腰椎骨密度有积极作用，提高了血清P1NP水平，同时降低了β-CTX水平。此外，MMF治疗降低了参与者的腰痛VAS评分。
动物和临床研究结果均表明，MMF治疗改善了骨转换，对提高骨密度有积极作用，并减轻了PMOP患者的腰痛。本研究将促进静磁场治疗骨质疏松症的转化研究和临床应用。
绝经后女性骨质疏松症和铁代谢的中度静磁场干预研究，中国临床试验注册中心注册号：ChiCTR2100048604
