Ma Zheying, Pan Shou, Yang Yaming, Ren Huiqian, Yin Sikun, Chen Qianyu, An Zhenxian, Zhao Xiaoqin, Xu Zujie
School of Physical Education and Health Engineering, Taiyuan University of Technology, Taiyuan, Shanxi 030024, China.
Institute of Sports Biology, College of Physical Education, Shaanxi Normal University, Xi'an 710119, China.
Ageing Res Rev. 2025 Jun;108:102758. doi: 10.1016/j.arr.2025.102758. Epub 2025 Apr 27.
Lipids metabolism is crucial in regulating aging and metabolic diseases. Lipid droplets (LDs) are dynamic, complex organelles responsible for the storage and release of neutral lipids, essential for maintaining lipid homeostasis and energy metabolism. Aging accelerates the accumulation of LDs, functional deterioration, and metabolic disorders, thereby inducing age-related metabolic diseases (ARMDs). This review examines published datasets on the association between LDs and ARMDs, focusing on the structure and function of LDs, their interactions with other organelles, and associated proteins. Furthermore, we explore the potential mechanisms by which LDs mediate the onset of ARMDs, including Alzheimer's disease (AD), sarcopenia, metabolic cardiomyopathy, non-alcoholic fatty liver disease (NAFLD), and cancer. Lastly, we discuss intervention strategies aimed at targeting LDs to improve outcomes in ARMDs, including exercise, dietary, and pharmacological interventions.
脂质代谢在调节衰老和代谢性疾病中起着至关重要的作用。脂滴（LDs）是动态的复杂细胞器，负责中性脂质的储存和释放，这对维持脂质稳态和能量代谢至关重要。衰老会加速脂滴的积累、功能恶化和代谢紊乱，从而引发与年龄相关的代谢性疾病（ARMDs）。本综述研究了已发表的关于脂滴与ARMDs之间关联的数据集，重点关注脂滴的结构和功能、它们与其他细胞器的相互作用以及相关蛋白质。此外，我们探讨了脂滴介导ARMDs发病的潜在机制，包括阿尔茨海默病（AD）、肌肉减少症、代谢性心肌病、非酒精性脂肪性肝病（NAFLD）和癌症。最后，我们讨论了旨在针对脂滴改善ARMDs预后的干预策略，包括运动、饮食和药物干预。
