Horefti Elina, Georgakopoulou Theano, Makka Sofia, Angelakis Emmanouil
National Measles and Rubella Reference Laboratory, Hellenic Pasteur Institute, Athens, Greece.
Department for Vaccine Preventable Diseases & Congenital Diseases, National Public Health Organization, Athens, Greece.
J Virol Methods. 2025 Jul;336:115171. doi: 10.1016/j.jviromet.2025.115171. Epub 2025 Apr 27.
Following the rise of measles cases on both a global and European level, the surveillance of the virus was strengthened even more in Greece, according to W.H.O. recommendations. Suspect cases were confirmed by using a combination of serological and molecular methods, whereas sequencing was implemented to determine the measles strains circulating in the country. In total, 18 cases were confirmed in February and March, with clusters of measles recorded in three administrative regions. Sequencing revealed that genotypes B3 and D8 were both present in the country and further phylogenetic analysis classified the D8 sequences into two sub-groups. The co-circulation of the B3 and D8 genotypes in Greece is consistent with data from other countries at the same time period. The use of both serological and molecular methods for the confirmation of measles cases is advisable, as it increases the possibility of assessing immunization gaps within the community as well as applying specific measures for the timely mitigation of the infection.
根据世界卫生组织的建议,在全球和欧洲层面麻疹病例上升之后,希腊对该病毒的监测得到了进一步加强。通过血清学和分子方法相结合来确诊疑似病例,同时进行测序以确定该国流行的麻疹毒株。2月和3月共确诊18例病例,在三个行政区记录到了麻疹聚集性病例。测序显示该国同时存在B3和D8基因型,进一步的系统发育分析将D8序列分为两个亚组。希腊B3和D8基因型的共同流行与同期其他国家的数据一致。建议使用血清学和分子方法来确诊麻疹病例,因为这增加了评估社区内免疫差距以及采取具体措施及时减轻感染的可能性。