Naess A, Halstensen A I, Solberg C O
Int Arch Allergy Appl Immunol. 1985;78(1):25-9. doi: 10.1159/000233857.
Blood leukocytes from 37 patients with acute bacterial infections, and cerebrospinal fluid (CSF) granulocytes from 12 patients with bacterial meningitis, were examined for the distribution of membrane receptors (R) for (1) untreated sheep erythrocytes (E), (2) the Fc portion of IgG (Fc gamma), and (3) complement component C3b. We found a decreased percentage of granulocytes bearing Fc gamma-R in the CSF from patients with meningitis, and in blood from patients with respiratory tract infections. This group also had a decreased percentage of C3b-R bearing granulocytes on admission, whereas meningitis patients had lower levels of C3b-R and Fc gamma-R bearing granulocytes in the 2nd and 3rd week and even later. Several patients with meningitis and gastroenteritis had granulocytes bearing the E-R, previously considered specific for T lymphocytes. Such cells were also found in the CSF. Meningitis and respiratory tract infections were associated with a decreased percentage of 'active' T lymphocytes. The total percentage of T lymphocytes was also decreased in meningitis. Conversely the proportion of Fc gamma-R bearing lymphocytes (consisting mostly of B lymphocytes) was increased in most infections. During the first 3 weeks of bacterial meningitis, the percentages of Fc gamma- and C3b-R bearing granulocytes, and of Fc gamma-R bearing lymphocytes, gradually decreased, while the T lymphocyte percentage increased from the initial low values.
对37例急性细菌感染患者的血液白细胞以及12例细菌性脑膜炎患者的脑脊液（CSF）粒细胞进行检测，以观察其对以下物质的膜受体（R）分布情况：（1）未处理的绵羊红细胞（E）；（2）IgG的Fc段（Fcγ）；（3）补体成分C3b。我们发现，脑膜炎患者脑脊液以及呼吸道感染患者血液中携带Fcγ-R的粒细胞百分比降低。该组患者入院时携带C3b-R的粒细胞百分比也降低，而脑膜炎患者在第二周、第三周及更晚时间，携带C3b-R和Fcγ-R的粒细胞水平较低。几名脑膜炎和肠胃炎患者的粒细胞携带E-R，而E-R以前被认为是T淋巴细胞特有的。这种细胞在脑脊液中也有发现。脑膜炎和呼吸道感染与“活跃”T淋巴细胞百分比降低有关。脑膜炎患者的T淋巴细胞总百分比也降低。相反，在大多数感染中，携带Fcγ-R的淋巴细胞（主要由B淋巴细胞组成）比例增加。在细菌性脑膜炎的前三周，携带Fcγ-和C3b-R的粒细胞以及携带Fcγ-R的淋巴细胞百分比逐渐降低，而T淋巴细胞百分比则从最初的低值开始增加。
