Barbero C, Biolino P, Calleri M, Zocche G P
Int J Clin Pharmacol Ther Toxicol. 1985 Jul;23(7):284-90.
Althesin was used in 65 patients with heart diseases undergoing orthopedic surgery, alone or in association with neuroleptanalgesic drugs. Patients were classified according to four types of heart diseases: atrial fibrillation in older patients (41.53%), disorders of cardiac rhythm (23.07%), valvular diseases (9.23%), ischemic heart disease (26.15%) and according to the degree of risk (ASA 3 and 4). All patients were carefully studied before the operation, and adequately treated with cardiac drugs in order to reduce heart rate, to reduce blood pressure and to reduce heart failure, whenever necessary. Anesthesia was induced with Althesin in all patients, and maintained with Althesin/N2O/O2 in 24.61% of the cases, and Althesin/N2O/O2/NLA in 75.39% of the cases. No significant changes in heart rate or in blood pressure were observed either during surgery or in the first 24 hours after the operation. There were five deaths in the days after the operation, one of which was due to surgery. One patient was discharged while still in a coma. All the other patients were discharged from the hospital within approximately four weeks from the day of the operation in good general condition. It was concluded that Althesin is a very reliable anesthetic agent for patients with heart diseases.
阿尔泰辛用于65例接受骨科手术的心脏病患者，单独使用或与神经安定镇痛药物联合使用。患者根据四种心脏病类型进行分类：老年患者房颤（41.53%）、心律失常（23.07%）、瓣膜病（9.23%）、缺血性心脏病（26.15%），并根据风险程度（ASA 3级和4级）进行分类。所有患者在手术前均经过仔细研究，并在必要时使用心脏药物进行充分治疗，以降低心率、降低血压和减轻心力衰竭。所有患者均用阿尔泰辛诱导麻醉，24.61%的病例用阿尔泰辛/氧化亚氮/氧气维持麻醉，75.39%的病例用阿尔泰辛/氧化亚氮/氧气/神经安定镇痛合剂维持麻醉。手术期间及术后24小时内，心率和血压均无明显变化。术后数天有5例死亡，其中1例死于手术。1例患者仍处于昏迷状态时出院。所有其他患者在术后约四周内出院，一般情况良好。得出的结论是，阿尔泰辛对心脏病患者是一种非常可靠的麻醉剂。
