中国云南省基于家庭的幽门螺杆菌感染的流行病学状况

Epidemiological status of family-based Helicobacter pylori infection in Yunnan Province, China.

作者信息

Wan Ying, Wu Yongmei, Yang Yunran, Zhou Qingqing, Li Yu, Wang Da, Zhang Dan, Na Kunpeng, Liu Lan, He Yule, Chen Hang, Huang Minshan, Cai Le, You Dingyun, Ma Lanqing

机构信息

Department of Gastroenterology, The First Affiliated Hospital, Yunnan Institute of Digestive Disease, Yunnan Clinical Research Center for Digestive Diseases, Kunming Medical University, 650032, Kunming, China.

Department of Gastroenterology, The First People's Hospital of Kunming, 650051, Kunming, China.

出版信息

BMC Gastroenterol. 2025 Apr 29;25(1):309. doi: 10.1186/s12876-025-03806-1.

DOI:10.1186/s12876-025-03806-1

PMID:40301812

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12039176/

Abstract

BACKGROUND

The status of family-based H. pylori infection in Yunnan Province is unknown. This study is the first family-based epidemiological survey of H. pylori in the province, aiming to provide new insights into the status of family-based H. pylori infections in Yunnan Province as well as in the country as a whole.

METHODS

Between 2021 and 2023, 1,176 families with 2,947 family members were tested for H. pylori in six cities in Yunnan Province with different geographic locations and economic status, to assess the status of H. pylori infection, and to clarify the related factors and modes of transmission by means of a questionnaire survey.

RESULTS

In Yunnan Province, the H. pylori infection rate was 31.46% (927/2947) in people and 54.59% (642/1176) in families.On the individual side, living outside of southern Yunnan (e.g., Central OR 1.41, 95% CI 1.10-1.81), having a family member living together for ≥ 1 year (OR 2.43, 95% CI 1.49-3.95), being ≥ 18 years old (e.g., 18-44 years old: OR 3.51, 95% CI 1.98-6.23), and gastrointestinal discomfort within the last 1 year (OR 1.25, 95% CI 1.04-1.50) were independent risk factors for H. pylori infection in the study population in Yunnan Province, whereas an education level of college/university and above (OR 0.62, 95% CI 0.48-0.79), and a gastroscopy within 5 years (OR 0.58, 95% CI 0.46-0.73) were independent protective factors for their H. pylori infection. In terms of family, living outside of southern Yunnan (e.g., Central OR 1.52, 95% CI 1.07-2.18), and having ≥ 3 people living together in the family (e.g., 3-4 people: OR 2.04, 95% CI 1.52-2.72) were independent risk factors for H. pylori infection in study families in Yunnan Province, whereas an annual household income of ≥ 100,000 ( OR 0.68, 95% CI 0.51-0.90), total household living area ≥ 60 m2 (OR 0.62, 95% CI 0.39-0.97), the use of separate meals for intra-household gatherings (OR 0.56, 95% CI 0.38-0.85), and the use of communal spoons and chopsticks (OR 0.38, 95% CI 0.28-0.52) were the independent protective factorse.

CONCLUSION

The risk factors of Family-Based H. pylori infection in Yunnan province were closely related to demographic characteristics, personal and family living habits. Close contact with infected family members may be the main cause of transmission. Family-based control of H. pylori infection should be regarded in clinical practice.

摘要

背景

云南省基于家庭的幽门螺杆菌感染状况尚不清楚。本研究是该省首次基于家庭的幽门螺杆菌流行病学调查，旨在为云南省乃至全国基于家庭的幽门螺杆菌感染状况提供新的见解。

方法

2021年至2023年期间，对云南省6个地理位置和经济状况不同的城市的1176个家庭、2947名家庭成员进行了幽门螺杆菌检测，以评估幽门螺杆菌感染状况，并通过问卷调查明确相关因素及传播方式。

结果

在云南省，人群中幽门螺杆菌感染率为31.46%（927/2947），家庭中为54.59%（642/1176）。在个体层面，居住在滇南以外地区（如中部：比值比1.41，95%置信区间1.10 - 1.81）、有家庭成员共同居住≥1年（比值比2.43，95%置信区间1.49 - 3.95）、年龄≥18岁（如18 - 44岁：比值比3.51，95%置信区间1.98 - 6.23）以及过去1年内有胃肠道不适（比值比1.25，95%置信区间1.04 - 1.50）是云南省研究人群幽门螺杆菌感染的独立危险因素，而大专及以上学历（比值比0.62，95%置信区间0.48 - 0.79）以及5年内进行过胃镜检查（比值比0.58，95%置信区间0.46 - 0.73）是其幽门螺杆菌感染的独立保护因素。在家庭层面，居住在滇南以外地区（如中部：比值比1.52，95%置信区间1.07 - 2.18）以及家庭中共同居住≥3人（如3 - 4人：比值比2.04，95%置信区间1.52 - 2.72）是云南省研究家庭幽门螺杆菌感染的独立危险因素，而家庭年收入≥10万（比值比0.68，95%置信区间0.51 - 0.90）、家庭总居住面积≥60平方米（比值比0.62，95%置信区间0.39 - 0.97）、家庭聚餐使用分餐制（比值比0.56，95%置信区间0.38 - 0.85）以及使用公筷公勺（比值比0.38，95%置信区间0.28 - 0.52）是独立保护因素。