Alén M, Rahkila P, Marniemi J
Int J Sports Med. 1985 Jun;6(3):139-44. doi: 10.1055/s-2008-1025827.
The purpose of the present investigation was to study the effects of testosterone and anabolic steroids on serum lipids in power athletes. Altogether 11 national top-level adult athletes completed the study. Five of them volunteered for the study group and the rest for controls. The follow-up consisted of 9 months of a strength training period. During the first 6 months, the subjects in the study group self-administered androgenic steroids on an average of 57 +/- 24.9 mg/day. The most interesting observation was the extremely low high-density lipoprotein (HDL) and HDL2 cholesterol concentrations of the androgen users. After 8 weeks of training, the study group had significantly (P less than 0.05) lower HDL cholesterol concentrations than the control group (0.53 +/- 0.11 and 1.14 +/- 0.19 mmol/l, respectively). This difference remained significant from 8 to 32 weeks of training. No systematic changes were observed in the control group. The HDL2 cholesterol concentration decreased by about 80% (P less than 0.01) and HDL3 cholesterol by about 55% (P less than 0.01) from the onset values in the study group. A substantial decrease in HDL cholesterol to total cholesterol and in HDL2 cholesterol to HDL3 cholesterol ratios were also noticed under the influence of exogenous androgens. The results of this study suggest that the sustained use of testosterone and anabolic steroids have a marked unfavorable effect on the pattern of HDL cholesterol in the serum of male power athletes.
本研究的目的是探讨睾酮和合成代谢类固醇对力量型运动员血脂的影响。共有11名国家顶级成年运动员完成了这项研究。其中5人自愿加入研究组，其余为对照组。随访包括9个月的力量训练期。在最初的6个月里，研究组的受试者平均每天自行服用雄激素类固醇57±24.9毫克。最有趣的观察结果是雄激素使用者的高密度脂蛋白（HDL）和HDL2胆固醇浓度极低。训练8周后，研究组的HDL胆固醇浓度显著低于对照组（P<0.05）（分别为0.53±0.11和1.14±0.19毫摩尔/升）。从训练的第8周到第32周，这种差异一直显著。对照组未观察到系统性变化。研究组的HDL2胆固醇浓度比起始值下降了约80%（P<0.01），HDL3胆固醇下降了约55%（P<0.01）。在外源性雄激素的影响下，HDL胆固醇与总胆固醇的比值以及HDL2胆固醇与HDL3胆固醇的比值也大幅下降。本研究结果表明，持续使用睾酮和合成代谢类固醇对男性力量型运动员血清中HDL胆固醇的模式有明显的不利影响。
