Jamieson T W, De Smet A A, Cremer M A, Kage K L, Lindsley H B
Invest Radiol. 1985 May-Jun;20(3):324-30. doi: 10.1097/00004424-198505000-00017.
Serial whole body and lateral hindpaw magnification radiographs were obtained on 15 rats with collagen-induced arthritis. The radiographs were evaluated for findings of inflammatory arthritis. Soft tissue swelling and juxta-articular osteopenia usually developed two weeks after immunization. The swelling remained stable for the remaining seven weeks of the study, but the osteopenia apparently improved. Three weeks after immunization, erosions and periostitis began to develop in ten of the rats. These latter radiographic changes rapidly worsened over the next three weeks and then stabilized. The most frequent and severe changes were seen in the intertarsal, tibiotalar, and metatarsophalangeal joints. The toes, forepaws, and knees were infrequently involved. Other peripheral joints and the axial skeleton were spared. Five rats developed soft tissue swelling but had no articular erosions or periostitis. Serial radiography has potential usefulness for monitoring the effects of treatment in this experimental model for inflammatory arthritis.
对15只胶原诱导性关节炎大鼠进行了系列全身和后足外侧放大X线摄影。对这些X线片进行评估，以寻找炎症性关节炎的表现。软组织肿胀和关节周围骨质减少通常在免疫后两周出现。在研究的剩余七周内，肿胀保持稳定，但骨质减少明显改善。免疫后三周，10只大鼠开始出现侵蚀和骨膜炎。这些后期的X线改变在接下来的三周内迅速恶化，然后稳定下来。最常见和严重的改变见于跗间关节、胫距关节和跖趾关节。脚趾、前足和膝关节很少受累。其他外周关节和中轴骨骼未受累。5只大鼠出现软组织肿胀，但没有关节侵蚀或骨膜炎。系列X线摄影对于监测该炎症性关节炎实验模型中的治疗效果具有潜在的用途。
