Lindsley H B, Jamieson T W, De Smet A A, Kimler B F, Cremer M A, Hassanein K M
Department of Medicine, University of Kansas Medical Center, Kansas City 66103.
J Rheumatol. 1988;15(5):742-4.
Collagen induced arthritis was elicited in rats and monitored with serial magnification radiographs and serologic studies. Total lymphoid irradiation (TLI), 1050 rad in 3 fractions, was given at 1 of 2 days after primary immunization. Erosive arthritis and periostitis evolved more slowly in rats irradiated on Day 9 compared to nonirradiated control animals; in contrast, rats irradiated on Day 21 showed no significant differences. At Day 114 neither group receiving TLI differed from nonirradiated controls. Additional groups of rats were irradiated at varying times relative to collagen immunization. On Day 18 the mean IgM and IgG anticollagen antibody responses were transiently decreased in animals receiving TLI by Day 9, with no differences by Day 36.
在大鼠中诱发胶原诱导性关节炎，并通过系列放大X线片和血清学研究进行监测。在初次免疫后第1天或第2天给予全身淋巴照射（TLI），分3次给予，每次1050拉德。与未照射的对照动物相比，在第9天接受照射的大鼠中，侵蚀性关节炎和骨膜炎的发展更为缓慢；相反，在第21天接受照射的大鼠没有显著差异。在第114天，接受TLI的两组与未照射的对照组均无差异。相对于胶原免疫，在不同时间对另外几组大鼠进行照射。在第18天，在第9天接受TLI的动物中，平均IgM和IgG抗胶原抗体反应短暂下降，在第36天无差异。
