C反应蛋白-白蛋白-淋巴细胞指数是I-III期结肠癌根治性切除术后复发和生存的有用指标。
C-reactive Protein-albumin-lymphocyte Index Is a Useful Indicator for Recurrence and Survival Following Curative Resection of Stage I-III Colorectal Cancer.
作者信息
Bekki Tomoaki, Shimomura Manabu, Yano Takuya, Watanabe Atsuhiro, Ishikawa Sho, Imaoka Kouki, Ono Kosuke, Matsubara Keiso, Mochizuki Tetsuya, Hattori Minoru, Akabane Shintaro, Ohdan Hideki
机构信息
Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Medical Education Center, Hiroshima University, Hiroshima, Japan.
出版信息
J Anus Rectum Colon. 2025 Apr 25;9(2):192-201. doi: 10.23922/jarc.2024-070. eCollection 2025.
OBJECTIVES
Recently, several simple inflammation-based prognostic scores that can be calculated easily from serum parameters, have been reported to be related to colorectal cancer prognosis. This study aimed to investigate factors influencing the prognosis of patients, including inflammation-based prognostic scores, with stage I-III colorectal cancer following curative resection.
METHODS
This single-center study included 608 patients with stage I-III colorectal cancer who underwent curative resection between April 2010 and December 2018. A retrospective analysis was performed to identify the prognosis-associated variables in these patients. As a multi-center study, the Hiroshima Surgical study Group of Clinical Oncology database was used to analyze 1659 patients with stage I-III colorectal cancer who underwent curative resection to confirm the results of our single-center study.
RESULTS
Of the inflammation-based prognostic scores, only preoperative C-reactive protein-albumin-lymphocyte index was revealed to predict a poor prognosis in patients with stage I-III colorectal cancer following curative resection. The low C-reactive protein-albumin-lymphocyte index was associated with poor overall survival and recurrence-free survival, which was similar in patients from multi-center database. The C-reactive protein-albumin-lymphocyte index was found to be associated with patient age, systemic condition, comorbidities, and tumor factors. The time-dependent area under the curve for the postoperative proghosis of the C-reactive protein-albumin-lymphocyte index was superior to those of other inflammation-based prognostic scores in most postoperative observation periods.
CONCLUSIONS
The preoperative C-reactive protein-albumin-lymphocyte index was independently associated with long-term prognosis in patients with stage I-III colorectal cancer following curative resection.
目的
最近，有报道称几种基于炎症的简单预后评分可根据血清参数轻松计算得出，与结直肠癌预后相关。本研究旨在调查影响I-III期结直肠癌根治性切除术后患者预后的因素，包括基于炎症的预后评分。
方法
这项单中心研究纳入了2010年4月至2018年12月期间接受根治性切除的608例I-III期结直肠癌患者。进行回顾性分析以确定这些患者中与预后相关的变量。作为一项多中心研究，使用广岛临床肿瘤外科学术研究组数据库分析了1659例接受根治性切除的I-III期结直肠癌患者，以证实我们单中心研究的结果。
结果
在基于炎症的预后评分中，仅术前C反应蛋白-白蛋白-淋巴细胞指数被发现可预测I-III期结直肠癌根治性切除术后患者的不良预后。低C反应蛋白-白蛋白-淋巴细胞指数与总体生存率和无复发生存率差相关，多中心数据库中的患者情况相似。发现C反应蛋白-白蛋白-淋巴细胞指数与患者年龄、全身状况、合并症和肿瘤因素相关。在大多数术后观察期，C反应蛋白-白蛋白-淋巴细胞指数术后预后的时间依赖性曲线下面积优于其他基于炎症的预后评分。
结论
术前C反应蛋白-白蛋白-淋巴细胞指数与I-III期结直肠癌根治性切除术后患者的长期预后独立相关。
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