Hawke Kate, Ng Soong Zheng, Anderson Jessica, Dharmaputra Raymond, Hogg Prue, Titmuss Angela, Sinha Ashim, McLean Anna
Diabetes and Endocrinology Department Cairns Hospital, 165 The Esplanade, Cairns, QLD 4870, Australia.
Logan Endocrine and Diabetes Services Logan Hospital, Loganlea Road, Meadowbrook, QLD 4131, Australia.
Pediatr Diabetes. 2024 Jun 14;2024:9926090. doi: 10.1155/2024/9926090. eCollection 2024.
To assess morbidity among young people with diabetes presenting to a regional hospital in Northern Australia and compare the risk of complications among those living with type 2 diabetes (T2D) versus type 1 diabetes (T1D).
A cross-sectional study of young people with T1D or T2D (diagnosed age 1-25 years) presenting to a regional Northern Australian hospital with any condition from 2015 to 2019. Demographics, cardiometabolic comorbidities, and diabetes-related complications were collected from individual medical records and compared between those with T1D and T2D.
Among 357 young people (192 had T2D, 165 T1D), the mean age was 22 years, the mean duration of diabetes was 6.7 years, 52% were Aboriginal or Torres Strait Islander, and 28% lived remotely. Cardiometabolic comorbidities (obesity, hypertension, and dyslipidaemia) and diabetes-related complications (microalbuminuria, amputation, and elevated non-alcoholic fatty liver disease score) were more prevalent in those with T2D compared to T1D, despite shorter disease duration and lower median HbA1c. When adjusted for age, sex, and BMI, the odds ratio (95% CI) for microalbuminuria was 4.8 (1.83-12.8) with T2D compared to T1D.
In a cohort of young people with diabetes in Northern Australia, the prevalence of diabetes-related complications was higher among those with T2D than T1D.
评估前往澳大利亚北部一家地区医院就诊的糖尿病青年患者的发病率，并比较2型糖尿病（T2D）患者与1型糖尿病（T1D）患者发生并发症的风险。
对2015年至2019年期间因任何病症前往澳大利亚北部一家地区医院就诊的1型或2型糖尿病青年患者（诊断年龄1 - 25岁）进行横断面研究。从个人病历中收集人口统计学信息、心脏代谢合并症和糖尿病相关并发症，并在1型糖尿病和2型糖尿病患者之间进行比较。
在357名青年患者中（192例为T2D，165例为T1D），平均年龄为22岁，糖尿病平均病程为6.7年，52%为原住民或托雷斯海峡岛民，28%居住在偏远地区。尽管T2D患者病程较短且HbA1c中位数较低，但与T1D患者相比，心脏代谢合并症（肥胖、高血压和血脂异常）以及糖尿病相关并发症（微量白蛋白尿、截肢和非酒精性脂肪肝病评分升高）在T2D患者中更为普遍。在对年龄、性别和BMI进行调整后，T2D患者发生微量白蛋白尿的比值比（95%置信区间）为4.8（1.83 - 12.8），而T1D患者为1。
在澳大利亚北部的一组糖尿病青年患者中，T2D患者糖尿病相关并发症的患病率高于T1D患者。
