Ghosh Amit Gourav, Kim Hie Lim, Khor Seik-Soon
Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore, Singapore.
GenomeAsia 100K Consortium, Singapore, Singapore.
Front Immunol. 2025 Apr 15;16:1473475. doi: 10.3389/fimmu.2025.1473475. eCollection 2025.
Dengue, a viral infection transmitted by mosquitoes, is an emerging global health threat exacerbated by climate change. Rising temperatures and altered precipitation patterns create favourable conditions for vector proliferation and extended transmission periods, increasing the risk of dengue in endemic regions and facilitating its spread to non-endemic areas. Understanding the interplay between critical genetic factors and dengue susceptibility is crucial for developing effective public health strategies. The genes encode proteins essential for an effective immune response against pathogens, and their genetic variations influence susceptibility to severe dengue. In this study, we conducted a comprehensive meta-analysis of alleles associated with dengue infection and dengue severity. We analysed 19 case-control studies on dengue infections in populations worldwide to infer associations with various pathological forms of dengue and to examine differences across different populations. Our findings indicate that increases susceptibility to dengue fever (DF), while increases the risk of Dengue Haemorrhagic Fever (DHF), with these increased susceptibilities primarily observed in Southeast Asian populations. Additionally, is associated with DHF and all symptomatic dengue infections (DEN), contributing to dengue risk in both Southeast Asia and the Caribbean. Conversely, and show a protective effect against DHF but show significant regional heterogeneity, highlighting divergent, population-specific susceptibility profiles. This study underscores the importance of population-specific genetic risk assessments for dengue infection and emphasizes the need for targeted medical interventions and improved predictive models to mitigate dengue's impact, especially as climate change accelerates disease spread.
登革热是一种由蚊子传播的病毒感染，是一种因气候变化而加剧的新出现的全球健康威胁。气温上升和降水模式改变为病媒繁殖和延长传播期创造了有利条件，增加了流行地区登革热的风险，并促使其传播到非流行地区。了解关键基因因素与登革热易感性之间的相互作用对于制定有效的公共卫生策略至关重要。这些基因编码对病原体产生有效免疫反应所必需的蛋白质，其基因变异影响对严重登革热的易感性。在本研究中，我们对与登革热感染和登革热严重程度相关的等位基因进行了全面的荟萃分析。我们分析了全球人群中19项关于登革热感染的病例对照研究，以推断与登革热各种病理形式的关联，并检查不同人群之间的差异。我们的研究结果表明，[基因名称1]会增加患登革热（DF）的易感性，而[基因名称2]会增加患登革出血热（DHF）的风险，这些易感性增加主要在东南亚人群中观察到。此外，[基因名称3]与DHF和所有有症状的登革热感染（DEN）相关，在东南亚和加勒比地区都增加了登革热风险。相反，[基因名称4]和[基因名称5]对DHF有保护作用，但存在显著的区域异质性，突出了不同的、特定人群的易感性特征。这项研究强调了针对登革热感染进行特定人群基因风险评估的重要性，并强调需要有针对性的医疗干预措施和改进的预测模型，以减轻登革热的影响，特别是在气候变化加速疾病传播的情况下。
