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研究多糖（PSP）对D-半乳糖诱导的衰老小鼠的肾脏保护作用：来自肠道微生物群和代谢组学分析的见解

Investigating the renoprotective effects of polysaccharides (PSP) on D-galactose-induced aging mice: insights from gut microbiota and metabolomics analyses.

作者信息

Huang Rui, Che Runli, Sun Taoli, Xie Wen, Zhang Shuihan

机构信息

Hunan Academy of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China.

The First People's Hospital of Changde City, Changde, China.

出版信息

Front Microbiol. 2025 Apr 15;16:1550971. doi: 10.3389/fmicb.2025.1550971. eCollection 2025.

DOI:10.3389/fmicb.2025.1550971
PMID:40303470
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12037495/
Abstract

INTRODUCTION

Polygonatum sibiricum polysaccharides (PSP) have been suggested to possess various health benefits, including anti-aging and renoprotective effects. However, the mechanisms underlying PSP's protective effects on kidney function, particularly in the context of aging, remain unclear. This study explores how PSP protects against D-galactose (D-gal)-induced kidney damage in aging mice, focusing on gut microbiota and metabolomics.

METHODS

Mice were assigned to five groups: control, model (D-gal), vitamin C, low-dose PSP, and high-dose PSP, and treated for 8 weeks. Kidney pathology was assessed via H&E and Masson's trichrome staining. 16S rRNA sequencing analyzed gut microbiota, and non-targeted metabolomics identified metabolic changes. Correlations between gut bacteria and metabolites were examined.

RESULTS

PSP alleviated renal damage, reducing tubular atrophy, epithelial swelling, and collagen deposition. It increased beneficial gut bacteria (e.g., Lactobacillus, Bifidobacterium) and altered 23 metabolites linked to pathways such as amino acid and sphingolipid metabolism. Gut microbiota and metabolites were strongly correlated, indicating PSP's role in regulating the gut-kidney axis.

CONCLUSION

PSP protects against age-related kidney damage by modulating gut microbiota and metabolic pathways, highlighting its therapeutic potential for kidney aging through the gut-kidney axis.

摘要

引言

已表明黄精多糖（PSP）具有多种健康益处，包括抗衰老和肾脏保护作用。然而，PSP对肾脏功能保护作用的潜在机制，尤其是在衰老背景下，仍不清楚。本研究探讨PSP如何保护衰老小鼠免受D-半乳糖（D-gal）诱导的肾脏损伤，重点关注肠道微生物群和代谢组学。

方法

将小鼠分为五组：对照组、模型组（D-gal）、维生素C组、低剂量PSP组和高剂量PSP组，并治疗8周。通过苏木精-伊红（H&E）染色和马松三色染色评估肾脏病理学。16S rRNA测序分析肠道微生物群，非靶向代谢组学鉴定代谢变化。检查肠道细菌与代谢物之间的相关性。

结果

PSP减轻了肾脏损伤，减少了肾小管萎缩、上皮肿胀和胶原沉积。它增加了有益的肠道细菌（如乳酸杆菌、双歧杆菌），并改变了23种与氨基酸和鞘脂代谢等途径相关的代谢物。肠道微生物群与代谢物密切相关，表明PSP在调节肠-肾轴中发挥作用。

结论

PSP通过调节肠道微生物群和代谢途径来保护免受与年龄相关的肾脏损伤，突出了其通过肠-肾轴对肾脏衰老的治疗潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b583/12037495/b397eeda4c06/fmicb-16-1550971-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b583/12037495/73706079b08f/fmicb-16-1550971-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b583/12037495/7e603358a3f8/fmicb-16-1550971-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b583/12037495/b397eeda4c06/fmicb-16-1550971-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b583/12037495/73706079b08f/fmicb-16-1550971-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b583/12037495/9d3c89dfa5ff/fmicb-16-1550971-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b583/12037495/7e603358a3f8/fmicb-16-1550971-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b583/12037495/b397eeda4c06/fmicb-16-1550971-g007.jpg

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