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D-半乳糖致衰老大鼠心脏的抗氧化作用。

Antioxidant Effect of Polysaccharides in D-Galactose-Induced Heart Aging Mice.

机构信息

Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.

Institute of Clinical Pharmacy, Central South University, Changsha, Hunan 410011, China.

出版信息

Biomed Res Int. 2021 Mar 29;2021:6688855. doi: 10.1155/2021/6688855. eCollection 2021.

DOI:10.1155/2021/6688855
PMID:33860051
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8024086/
Abstract

polysaccharides (PSP), the extract of , are demonstrated to exhibit a wide range of pharmacological activities. A recent study reported that PSP alleviated the aging of the kidney and meninges. However, the effect of PSP on heart aging remains unclear. The present study is aimed at investigating the protection of PSP on D-galactose- (D-gal-) induced heart aging. Results showed that irregularly arranged cardiac muscle fibers were observed in heart tissues of D-gal-treated mice, and the levels of cardiac troponin T (cTnT), creatine kinase (CK), p21, and p53 were increased after D-gal treatment. D-gal-induced heart aging and injury can be attenuated by oral administration of PSP. Moreover, PSP also decreased reactive oxygen species (ROS) and malondialdehyde (MDA) and increased the level of superoxide dismutase (SOD) in the hearts of D-gal-treated mice. DNA damages and lipid peroxidation induced by oxidative stress were also inhibited by PSP as indicated by reduced levels of 8-hydroxydeoxyguanosine (8-OHdG) and 4-hydroxy-2-nonenal (4-HNE). Collectively, PSP attenuated D-gal-induced heart aging via inhibiting oxidative stress, suggesting that PSP might serve as a potential effective Chinese herbal active constituent for antiaging therapy.

摘要

多糖（PSP）是 的提取物，已被证明具有广泛的药理活性。最近的一项研究表明，PSP 可减轻肾脏和脑膜的衰老。然而，PSP 对心脏衰老的影响尚不清楚。本研究旨在探讨 PSP 对 D-半乳糖（D-gal）诱导的心脏衰老的保护作用。结果表明，D-gal 处理的小鼠心脏组织中观察到心肌纤维排列不规则，D-gal 处理后心肌肌钙蛋白 T（cTnT）、肌酸激酶（CK）、p21 和 p53 水平升高。PSP 口服可减轻 D-gal 诱导的心脏衰老和损伤。此外，PSP 还降低了 D-gal 处理小鼠心脏中的活性氧（ROS）和丙二醛（MDA）水平，并增加了超氧化物歧化酶（SOD）的水平。氧化应激诱导的 DNA 损伤和脂质过氧化也被 PSP 抑制，如 8-羟基脱氧鸟苷（8-OHdG）和 4-羟基-2-壬烯醛（4-HNE）水平降低所表明。综上所述，PSP 通过抑制氧化应激减轻 D-gal 诱导的心脏衰老，表明 PSP 可能是一种潜在有效的中草药抗衰老治疗活性成分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e591/8024086/bd5a178c96ae/BMRI2021-6688855.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e591/8024086/22f9b58b4e48/BMRI2021-6688855.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e591/8024086/cb465e9c727f/BMRI2021-6688855.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e591/8024086/85eb029c6ea0/BMRI2021-6688855.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e591/8024086/bd5a178c96ae/BMRI2021-6688855.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e591/8024086/22f9b58b4e48/BMRI2021-6688855.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e591/8024086/cb465e9c727f/BMRI2021-6688855.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e591/8024086/85eb029c6ea0/BMRI2021-6688855.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e591/8024086/bd5a178c96ae/BMRI2021-6688855.004.jpg

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本文引用的文献

[1]
Salivary Oxidative Stress Increases With the Progression of Chronic Heart Failure.

J Clin Med. 2020-3-12

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Protective effect of Polygonatum sibiricum Polysaccharide on D-galactose-induced aging rats model.

Sci Rep. 2020-2-10

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CD38 Deficiency Alleviates D-Galactose-Induced Myocardial Cell Senescence Through NAD/Sirt1 Signaling Pathway.

Front Physiol. 2019-9-3

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Eur J Pharmacol. 2018-10-21

[10]
Nicotine Modulates Cognitive Function in -Galactose-Induced Senescence in Mice.

Front Aging Neurosci. 2018-7-13

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