Xiao Yuming, Yan Zhou, Ren Fangyuan, Tan Yurong
College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Department of Obstetrics, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou 410017, China.
Int J Med Sci. 2025 Mar 31;22(9):2010-2019. doi: 10.7150/ijms.110104. eCollection 2025.
Bacterial exotoxins are protein- or peptide-based substances secreted by bacteria with high toxicity and specificity. They have diverse mechanisms of action on host cells, leading to host injury by destroying the cellular structure or interfering with physiological functions. With the continuous progress in biotechnology, bacterial exotoxins have broad application prospects in immunotherapy, vaccine development, drug design, and other fields. Appropriate modification of exotoxins can lead to the preparation of highly efficient immune agents and targeted drugs, which brings new hope for overcoming difficult diseases. This study provides a comprehensive and in-depth introduction to the application of bacterial exotoxins in the field of medicine and further explores the potential value of bacterial exotoxins, which is expected to make greater contributions to human health in the future.
细菌外毒素是细菌分泌的基于蛋白质或肽的物质，具有高毒性和特异性。它们对宿主细胞有多种作用机制，通过破坏细胞结构或干扰生理功能导致宿主损伤。随着生物技术的不断进步，细菌外毒素在免疫治疗、疫苗开发、药物设计等领域具有广阔的应用前景。对外毒素进行适当修饰可制备高效免疫剂和靶向药物，为攻克疑难疾病带来新希望。本研究全面深入地介绍了细菌外毒素在医学领域的应用，并进一步探索了细菌外毒素的潜在价值，有望在未来为人类健康做出更大贡献。
