Mekki Liena B, Elhassan Yasir H, Badi Rehab M, Shazali Ahmed F, Mojaddidi Moaz A, Ibrahim Sara, Abdalla Hussein A, Elsawaf Zeinab, Mohammedali Alfarazdeg A, Saeed Amal
Department of Medical Physiology, Elrazi University, Khartoum, SDN.
Department of Basic Medical Sciences, Taibah University, Madinah, SAU.
Cureus. 2025 Mar 30;17(3):e81451. doi: 10.7759/cureus.81451. eCollection 2025 Mar.
This study was to determine the prevalence of metabolic syndrome (MetS) and obesity in young adults from Sudan, investigate their effect on plasma levels of oxytocin, and examine the association of oxytocin level with the determinants of metabolic syndrome and obesity.
This was a cross-sectional study that included 202 young adults. Random sampling was applied to recruit volunteers from Ribat University, Khartoum, Sudan. Blood pressure, waist circumference, and plasma lipids were measured and applied for the diagnosis of metabolic syndrome according to the National Cholesterol Education Program - Adult Treatment Panel III (NCEP ATP III) criteria. Fasting blood glucose and insulin were used to validate the insulin resistance in patients with MetS. Oxytocin was measured using enzyme-linked immunosorbent assay (ELISA).
Metabolic syndrome was diagnosed in 29 students (14.36%). Mean oxytocin level was significantly higher in students with MetS (10.34 pg/mL, N=29) compared with students without MetS (9.15 pg/mL, N=174) (P < 0.001). Mean oxytocin level did not differ between students with homeostatic model assessment for insulin resistance (HOMA-IR) ≥ 2.5 (N=47), and without HOMA-IR < 2.5 (N=155); the oxytocin level was 9.53 pg/mL and 9.25 pg/mL, respectively (P = 0.068). Moderate positive correlations existed between oxytocin and waist circumference, BMI, body weight, triglycerides (TG), hip circumference, and high-density lipoprotein (HDL; P < 0.001). Oxytocin did not correlate with fasting blood glucose.
Oxytocin levels increased in young adults with MetS. Oxytocin levels correlate positively with BMI, waist circumference, blood pressure, triglycerides, and HDL.
本研究旨在确定苏丹年轻成年人中代谢综合征（MetS）和肥胖症的患病率，调查它们对血浆催产素水平的影响，并研究催产素水平与代谢综合征及肥胖症决定因素之间的关联。
这是一项横断面研究，纳入了202名年轻成年人。采用随机抽样的方法从苏丹喀土穆的里巴特大学招募志愿者。测量血压、腰围和血脂，并根据美国国家胆固醇教育计划成人治疗小组第三次报告（NCEP ATP III）标准用于诊断代谢综合征。空腹血糖和胰岛素用于验证代谢综合征患者的胰岛素抵抗。采用酶联免疫吸附测定法（ELISA）测量催产素。
29名学生（14.36%）被诊断为代谢综合征。与未患代谢综合征的学生（9.15 pg/mL，N = 174）相比，患代谢综合征的学生（10.34 pg/mL，N = 29）的平均催产素水平显著更高（P < 0.001）。胰岛素抵抗稳态模型评估（HOMA-IR）≥2.5的学生（N = 47）和HOMA-IR < 2.5的学生（N = 155）之间的平均催产素水平无差异；催产素水平分别为9.53 pg/mL和9.25 pg/mL（P = 0.068）。催产素与腰围、体重指数、体重、甘油三酯（TG）、臀围和高密度脂蛋白（HDL）之间存在中度正相关（P < 0.001）。催产素与空腹血糖无相关性。
患代谢综合征的年轻成年人的催产素水平升高。催产素水平与体重指数、腰围、血压、甘油三酯和高密度脂蛋白呈正相关。
