Janocha-Litwin Justyna, Simon Krzysztof
Department of Infectious Disease and Hepatology, Medical University of Wroclaw, Wroclaw, Poland.
First Department of Infectious Diseases, J. Gromkowski Specialistic Regional Hospital, Wroclaw, Poland.
Clin Exp Hepatol. 2025 Mar;11(1):1-8. doi: 10.5114/ceh.2025.148265. Epub 2025 Mar 31.
Patients with chronic liver diseases, particularly those with liver cirrhosis, are more vulnerable to severe superinfections compared to the general population. They face an increased risk of liver function decompensation and mortality when contracting viral or bacterial infections. Vaccination is crucial in mitigating these risks, yet its efficacy in this patient group may be limited. Despite the safety of vaccines, their effectiveness in individuals with chronic liver diseases remains constrained. A significant challenge is the inadequate implementation of vaccination protocols, often due to insufficient communication and recommendations from physicians, including hepatologists, and the high cost of vaccines.
慢性肝病患者，尤其是肝硬化患者，与普通人群相比更容易发生严重的重叠感染。他们在感染病毒或细菌时，肝功能失代偿和死亡的风险会增加。接种疫苗对于降低这些风险至关重要，但其在该患者群体中的疗效可能有限。尽管疫苗安全，但它们在慢性肝病患者中的有效性仍然受限。一个重大挑战是疫苗接种方案实施不足，这通常是由于包括肝病专家在内的医生沟通和建议不足以及疫苗成本高昂所致。
