文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

含普立泊醇部分的聚（1,4-环己烷二甲酸丁二醇酯）柔性无规共聚物的合成作为血管应用潜在候选物：固态表征及初步生物相容性和血液相容性

Synthesis of Flexible Random Copolymers of Poly(butylene -1,4-ciclohexanedicarboxylate) Containing Pripol Moiety as Potential Candidates for Vascular Applications: Solid-State Characterization and Preliminary Biocompatibility and Hemocompatibility.

作者信息

Bondi Edoardo, Bloise Nora, Soccio Michelina, Guidotti Giulia, Motta Ilenia, Gazzano Massimo, Ruggeri Marco, Fassina Lorenzo, Genini Emilia, Visai Livia, Pasquinelli Gianandrea, Lotti Nadia

机构信息

Department of Civil, Chemical, Environmental, and Materials Engineering, University of Bologna, Via Terracini 28, Bologna 40131, Italy.

Molecular Medicine Department (DMM), Centre for Health Technologies (CHT), Unità di Ricerca (UdR) INSTM, University of Pavia, Pavia 27100, Italy.

出版信息

Biomacromolecules. 2025 May 12;26(5):2882-2899. doi: 10.1021/acs.biomac.4c01668. Epub 2025 Apr 30.

DOI:10.1021/acs.biomac.4c01668
PMID:40304031
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12076511/
Abstract

In order to envisage new solutions for complications associated with cardiovascular diseases, including the occlusion of small vessels, a family of random copolymers of poly(butylene -1,4-ciclohexanedicarboxylate) (PBCE), containing Pripol moiety, namely, poly(butylene -1,4-ciclohexaendicarboxylate/Pripol), were successfully synthesized. The copolymers display reduced crystallinity and stiffness compared with PBCE, exhibiting elastic modulus values that are comparable to those of materials previously investigated for similar applications. The stability of the materials under physiological conditions was demonstrated over an extended time. Cytotoxicity was confirmed by a direct contact assay with human umbilical vein endothelial cells (HUVECs), and blood compatibility was established by the absence of any change in the values of activated prothrombin time and activated partial thromboplastin time, in addition to the low adhesion of blood components. The results demonstrated that the ad hoc design is pivotal in regulating solid state and functional properties, thereby facilitating the development of innovative materials for vascular tissue engineering.

摘要

为了设想与心血管疾病相关并发症的新解决方案，包括小血管闭塞，成功合成了一族含有普立泊部分的聚（1,4-环己烷二甲酸丁二醇酯）（PBCE）无规共聚物，即聚（1,4-环己烷二甲酸丁二醇酯/普立泊）。与PBCE相比，这些共聚物的结晶度和硬度降低，其弹性模量值与先前研究用于类似应用的材料相当。材料在生理条件下的稳定性在较长时间内得到了证明。通过与人脐静脉内皮细胞（HUVECs）的直接接触试验证实了细胞毒性，并且除了血液成分的低粘附性之外，通过活化凝血酶原时间和活化部分凝血活酶时间的值没有任何变化确定了血液相容性。结果表明，特殊设计在调节固态和功能特性方面至关重要，从而有助于开发用于血管组织工程的创新材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f81/12076511/1e8e72270de3/bm4c01668_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f81/12076511/b47b109b9af2/bm4c01668_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f81/12076511/dcb490da6614/bm4c01668_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f81/12076511/8a06164e5a92/bm4c01668_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f81/12076511/7dee5cb3445d/bm4c01668_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f81/12076511/274f7bf350a3/bm4c01668_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f81/12076511/b56a59bec835/bm4c01668_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f81/12076511/3809f819b49a/bm4c01668_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f81/12076511/2edecc486b00/bm4c01668_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f81/12076511/9b71d4b3e16c/bm4c01668_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f81/12076511/ad47dd446be7/bm4c01668_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f81/12076511/1e8e72270de3/bm4c01668_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f81/12076511/b47b109b9af2/bm4c01668_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f81/12076511/dcb490da6614/bm4c01668_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f81/12076511/8a06164e5a92/bm4c01668_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f81/12076511/7dee5cb3445d/bm4c01668_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f81/12076511/274f7bf350a3/bm4c01668_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f81/12076511/b56a59bec835/bm4c01668_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f81/12076511/3809f819b49a/bm4c01668_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f81/12076511/2edecc486b00/bm4c01668_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f81/12076511/9b71d4b3e16c/bm4c01668_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f81/12076511/ad47dd446be7/bm4c01668_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f81/12076511/1e8e72270de3/bm4c01668_0010.jpg

相似文献

[1]
Synthesis of Flexible Random Copolymers of Poly(butylene -1,4-ciclohexanedicarboxylate) Containing Pripol Moiety as Potential Candidates for Vascular Applications: Solid-State Characterization and Preliminary Biocompatibility and Hemocompatibility.

Biomacromolecules. 2025-5-12

[2]
Poly(butylene succinate) and its copolymers: research, development and industrialization.

Biotechnol J. 2010-11

[3]
Novel ether-linkages containing aliphatic copolyesters of poly(butylene 1,4-cyclohexanedicarboxylate) as promising candidates for biomedical applications.

Mater Sci Eng C Mater Biol Appl. 2014-1-1

[4]
Elastomeric Electrospun Scaffolds of a Biodegradable Aliphatic Copolyester Containing PEG-Like Sequences for Dynamic Culture of Human Endothelial Cells.

Biomolecules. 2020-11-30

[5]
Novel Nanostructured Scaffolds of Poly(butylene -1,4-cyclohexanedicarboxylate)-Based Copolymers with Tailored Hydrophilicity and Stiffness: Implication for Tissue Engineering Modeling.

Nanomaterials (Basel). 2023-8-14

[6]
Short fluorocarbon chains containing hydrophobic nanofibrous membranes with improved hemocompatibility, anticoagulation and anti-fouling performance.

Colloids Surf B Biointerfaces. 2019-1-14

[7]
[Synthesis, characterization and blood compatibility studies of waterproof breathable polyurethanes].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2005-8

[8]
Design and characterization of sulfobetaine-containing terpolymer biomaterials.

Acta Biomater. 2012-4-11

[9]
Poly(glycerol sebacate)/poly(butylene succinate-butylene dilinoleate) fibrous scaffolds for cardiac tissue engineering.

Tissue Eng Part C Methods. 2015-6

[10]
New biotextiles for tissue engineering: development, characterization and in vitro cellular viability.

Acta Biomater. 2013-5-30

本文引用的文献

[1]
Biological Materials for Tissue-Engineered Vascular Grafts: Overview of Recent Advancements.

Biomolecules. 2023-9-14

[2]
The ad hoc chemical design of random PBS-based copolymers influences the activation of cardiac differentiation while altering the HYPPO pathway target genes in hiPSCs.

Biomater Adv. 2023-11

[3]
Enhanced hemocompatibility and antibacterial activity of biodegradable poly(ester-urethane) modified with quercetin and phosphorylcholine for durable blood-contacting applications.

J Mater Chem B. 2023-6-28

[4]
Challenges and advances in materials and fabrication technologies of small-diameter vascular grafts.

Biomater Res. 2023-6-8

[5]
Biodegradation of Biodegradable Polymers in Mesophilic Aerobic Environments.

Int J Mol Sci. 2022-10-12

[6]
Review of Polymeric Biomimetic Small-Diameter Vascular Grafts to Tackle Intimal Hyperplasia.

ACS Omega. 2022-6-21

[7]
Biofabrication of small diameter tissue-engineered vascular grafts.

Acta Biomater. 2022-1-15

[8]
Highly Stretchable Fully Biomass Autonomic Self-Healing Polyamide Elastomers and Their Foam for Selective Oil Absorption.

Polymers (Basel). 2021-9-13

[9]
Chemical Modification of Poly(butylene -1,4-cyclohexanedicarboxylate) by Camphor: A New Example of Bio-Based Polyesters for Sustainable Food Packaging.

Polymers (Basel). 2021-8-13

[10]
Review: Tissue Engineering of Small-Diameter Vascular Grafts and Their In Vivo Evaluation in Large Animals and Humans.

Cells. 2021-3-23

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索