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含普立泊醇部分的聚（1,4-环己烷二甲酸丁二醇酯）柔性无规共聚物的合成作为血管应用潜在候选物：固态表征及初步生物相容性和血液相容性

Synthesis of Flexible Random Copolymers of Poly(butylene -1,4-ciclohexanedicarboxylate) Containing Pripol Moiety as Potential Candidates for Vascular Applications: Solid-State Characterization and Preliminary Biocompatibility and Hemocompatibility.

作者信息

Bondi Edoardo, Bloise Nora, Soccio Michelina, Guidotti Giulia, Motta Ilenia, Gazzano Massimo, Ruggeri Marco, Fassina Lorenzo, Genini Emilia, Visai Livia, Pasquinelli Gianandrea, Lotti Nadia

机构信息

Department of Civil, Chemical, Environmental, and Materials Engineering, University of Bologna, Via Terracini 28, Bologna 40131, Italy.

Molecular Medicine Department (DMM), Centre for Health Technologies (CHT), Unità di Ricerca (UdR) INSTM, University of Pavia, Pavia 27100, Italy.

出版信息

Biomacromolecules. 2025 May 12;26(5):2882-2899. doi: 10.1021/acs.biomac.4c01668. Epub 2025 Apr 30.

DOI:10.1021/acs.biomac.4c01668
PMID:40304031
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12076511/
Abstract

In order to envisage new solutions for complications associated with cardiovascular diseases, including the occlusion of small vessels, a family of random copolymers of poly(butylene -1,4-ciclohexanedicarboxylate) (PBCE), containing Pripol moiety, namely, poly(butylene -1,4-ciclohexaendicarboxylate/Pripol), were successfully synthesized. The copolymers display reduced crystallinity and stiffness compared with PBCE, exhibiting elastic modulus values that are comparable to those of materials previously investigated for similar applications. The stability of the materials under physiological conditions was demonstrated over an extended time. Cytotoxicity was confirmed by a direct contact assay with human umbilical vein endothelial cells (HUVECs), and blood compatibility was established by the absence of any change in the values of activated prothrombin time and activated partial thromboplastin time, in addition to the low adhesion of blood components. The results demonstrated that the ad hoc design is pivotal in regulating solid state and functional properties, thereby facilitating the development of innovative materials for vascular tissue engineering.

摘要

为了设想与心血管疾病相关并发症的新解决方案，包括小血管闭塞，成功合成了一族含有普立泊部分的聚（1,4-环己烷二甲酸丁二醇酯）（PBCE）无规共聚物，即聚（1,4-环己烷二甲酸丁二醇酯/普立泊）。与PBCE相比，这些共聚物的结晶度和硬度降低，其弹性模量值与先前研究用于类似应用的材料相当。材料在生理条件下的稳定性在较长时间内得到了证明。通过与人脐静脉内皮细胞（HUVECs）的直接接触试验证实了细胞毒性，并且除了血液成分的低粘附性之外，通过活化凝血酶原时间和活化部分凝血活酶时间的值没有任何变化确定了血液相容性。结果表明，特殊设计在调节固态和功能特性方面至关重要，从而有助于开发用于血管组织工程的创新材料。

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Biomolecules. 2023 Sep 14;13(9):1389. doi: 10.3390/biom13091389.
2
The ad hoc chemical design of random PBS-based copolymers influences the activation of cardiac differentiation while altering the HYPPO pathway target genes in hiPSCs.基于 PBS 的无规共聚物的特殊化学设计影响 hiPSCs 中心脏分化的激活，同时改变 HYPPO 通路靶基因。
Biomater Adv. 2023 Nov;154:213583. doi: 10.1016/j.bioadv.2023.213583. Epub 2023 Aug 12.
3
Enhanced hemocompatibility and antibacterial activity of biodegradable poly(ester-urethane) modified with quercetin and phosphorylcholine for durable blood-contacting applications.
用槲皮素和磷酰胆碱改性可生物降解的聚酯-聚氨酯以提高其血液相容性和抗菌活性，用于持久的血液接触应用。
J Mater Chem B. 2023 Jun 28;11(25):5846-5855. doi: 10.1039/d3tb00596h.
4
Challenges and advances in materials and fabrication technologies of small-diameter vascular grafts.小口径血管移植物的材料与制造技术的挑战与进展
Biomater Res. 2023 Jun 8;27(1):58. doi: 10.1186/s40824-023-00399-2.
5
Biodegradation of Biodegradable Polymers in Mesophilic Aerobic Environments.好氧嗜温环境中可生物降解聚合物的生物降解。
Int J Mol Sci. 2022 Oct 12;23(20):12165. doi: 10.3390/ijms232012165.
6
Review of Polymeric Biomimetic Small-Diameter Vascular Grafts to Tackle Intimal Hyperplasia.用于解决内膜增生的聚合物仿生小口径血管移植物综述。
ACS Omega. 2022 Jun 21;7(26):22125-22148. doi: 10.1021/acsomega.2c01740. eCollection 2022 Jul 5.
7
Biofabrication of small diameter tissue-engineered vascular grafts.组织工程小口径血管移植物的生物制造。
Acta Biomater. 2022 Jan 15;138:92-111. doi: 10.1016/j.actbio.2021.11.012. Epub 2021 Nov 13.
8
Highly Stretchable Fully Biomass Autonomic Self-Healing Polyamide Elastomers and Their Foam for Selective Oil Absorption.高拉伸性全生物质自主自愈合聚酰胺弹性体及其用于选择性吸油的泡沫材料
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Chemical Modification of Poly(butylene -1,4-cyclohexanedicarboxylate) by Camphor: A New Example of Bio-Based Polyesters for Sustainable Food Packaging.樟脑对聚（1,4 - 环己烷二甲酸丁二醇酯）的化学改性：用于可持续食品包装的生物基聚酯新实例
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Review: Tissue Engineering of Small-Diameter Vascular Grafts and Their In Vivo Evaluation in Large Animals and Humans.综述：小直径血管移植物的组织工程及其在大动物和人体内的体内评估。
Cells. 2021 Mar 23;10(3):713. doi: 10.3390/cells10030713.