Wolfensberger M, Fisch U
HNO. 1985 Jul;33(7):307-10.
When nasopharyngeal cancer recurs after radiotherapy, and when the dura is not invaded, radical excision is still possible by means of the infratemporal fossa approach (ITFA), developed by the senior author. In an effort to improve the results of radiotherapy, 13 cases of residual or persistent disease were operated on by this approach between 1977 and 1981. Of seven patients with T4 tumours, all died of persistent disease within two to three years. Six patients with T1 or T2 non-keratinizing squamous cell carcinoma are alive two to five years after surgery. Only one patient needed additional surgery for another recurrence. The approach results in a complete conductive hearing loss and permanent anaesthesia of the mandibular nerve. The procedure is safe and well tolerated. Average hospital stay is 14 days. A combination of radiotherapy and surgery is recommended for T1 and T2 carcinoma in order to improve longterm survival rates.
鼻咽癌放疗后复发且未侵犯硬脑膜时，资深作者所采用的颞下窝入路（ITFA）仍有可能进行根治性切除。为提高放疗效果，1977年至1981年间，采用该入路对13例残留或持续性疾病患者进行了手术。7例T4期肿瘤患者均在两到三年内死于持续性疾病。6例T1或T2期非角化鳞状细胞癌患者术后存活两到五年。仅1例患者因再次复发需要再次手术。该入路会导致完全性传导性听力丧失和下颌神经永久性麻醉。该手术安全且耐受性良好。平均住院时间为14天。对于T1和T2期癌，建议放疗与手术联合应用以提高长期生存率。
