一种具有抗胃壁细胞自身抗原活性的骨髓瘤蛋白中的人免疫球蛋白。
A human immunoglobulin in myeloma protein with anti-gastric parietal cell autoantigen activity.
作者信息
Micouin C, Rivat C, Bensa J C, Stoebner P, Favre M, Hudry E
出版信息
Clin Exp Immunol. 1977 Jan;27(1):78-84.
A previously characterised IgA Kappa myeloma protein was isolated and purified. The (Fab) alpha fragments of this immunoglobulin were obtained. The IgA and Fab fragments reacted in vitro with gastric parietal cells (GPC) using animal gastric sections and with smooth cytoplasmic membranes obtained from rabbit fundus (gastric) mucosa. This was seen macroscopically and by light and electron microscopy. Evidence is thus provided which supports the concept that this homogeneous immunoglobulin is a typical monoclonal autoantibody.
分离并纯化了一种先前已鉴定的IgA κ型骨髓瘤蛋白。获得了该免疫球蛋白的（Fab）α片段。使用动物胃切片，IgA和Fab片段在体外与胃壁细胞（GPC）反应，并与从兔胃底（胃）黏膜获得的光滑细胞质膜反应。这在宏观上以及通过光学显微镜和电子显微镜都能看到。因此提供了证据支持这种同源免疫球蛋白是典型单克隆自身抗体这一概念。
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