Suppr超能文献

IgA可溶性免疫复合物对中性粒细胞趋化作用的抑制效应。

Suppressive effect of IgA soluble immune complexes on neutrophil chemotaxis.

作者信息

Ito S, Mikawa H, Shinomiya K, Yoshida T

出版信息

Clin Exp Immunol. 1979 Sep;37(3):436-40.

PMID:116785
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537781/
Abstract

The effect of IgA and IgG soluble immune complexes (SIC) on neutrophil chemotaxis was investigated. Six types of SIC were prepared from kappa-type IgA and IgG myeloma proteins: IgA-anti-kappa chain antibody SIC in IgA excess, IgA-anti-kappa chain antibody in SIC in anti-kappa chain antibody excess, IgA-anti-alpha chain antibody SIC in IgA excess, IgG-anti-kappa chain antibody SIC in IgG excess, IgG-anti-kappa chain antibody SIC in anti-kappa chain antibody excess, and IgG-anti-gamma chain antibody SIC in IgG excess. Three types of IgA SIC had a marked suppressive effect on neutrophil chemotaxis, while IgG SIC, free IgA, free anti-kappa chain antibody, and free anti-gamma chain antibody showed no inhibitory activity. This suppressive effect on neutrophil chemotaxis caused specifically by polymerized IgA was a cell-directed one and was expressed in a concentration dependent manner.

摘要

研究了IgA和IgG可溶性免疫复合物（SIC）对中性粒细胞趋化性的影响。由κ型IgA和IgG骨髓瘤蛋白制备了六种类型的SIC：IgA过量的IgA-抗κ链抗体SIC、抗κ链抗体过量的IgA-抗κ链抗体SIC、IgA过量的IgA-抗α链抗体SIC、IgG过量的IgG-抗κ链抗体SIC、抗κ链抗体过量的IgG-抗κ链抗体SIC以及IgG过量的IgG-抗γ链抗体SIC。三种类型的IgA SIC对中性粒细胞趋化性有显著的抑制作用，而IgG SIC、游离IgA、游离抗κ链抗体和游离抗γ链抗体均无抑制活性。这种由聚合IgA特异性引起的对中性粒细胞趋化性的抑制作用是细胞定向的，并以浓度依赖的方式表现出来。

相似文献

1
Suppressive effect of IgA soluble immune complexes on neutrophil chemotaxis.IgA可溶性免疫复合物对中性粒细胞趋化作用的抑制效应。
Clin Exp Immunol. 1979 Sep;37(3):436-40.
2
Suppressive effect of IgE soluble immune complex on neutrophil chemotaxis.IgE可溶性免疫复合物对中性粒细胞趋化性的抑制作用。
Clin Exp Immunol. 1983 Feb;51(2):407-12.
3
Three M components IgA lambda, + IgG kappa n + IgG kappa h in one patient. II. Structurally different kappa n and kappa h chains associated with H(gamma) chains sharing idiotypic determinants.一名患者体内存在三种M成分：IgA λ、+ IgG κn + IgG κh。二、与共享独特型决定簇的H(γ)链相关的结构不同的κn和κh链。
J Immunol. 1982 Oct;129(4):1519-24.
4
Role of beta 1, beta 2 integrins and ICAM-1 in lung injury after deposition of IgG and IgA immune complexes.β1、β2整合素及细胞间黏附分子-1在IgG和IgA免疫复合物沉积后肺损伤中的作用
J Immunol. 1993 Mar 15;150(6):2407-17.
5
Modulation of the murine immune response to human IgG by complexing with monoclonal antibodies. I. Antibody responses to determinants on the constant region of light chains and gamma chains.通过与单克隆抗体复合来调节小鼠对人IgG的免疫反应。I. 针对轻链和γ链恒定区上决定簇的抗体反应。
Immunology. 1987 Sep;62(1):1-6.
6
Contrasting roles for tumor necrosis factor in the pathogeneses of IgA and IgG immune complex lung injury.肿瘤坏死因子在IgA和IgG免疫复合物所致肺损伤发病机制中的不同作用
Am J Pathol. 1991 Mar;138(3):581-90.
7
Normal human sera contain antibodies directed at Fab of IgA.正常人血清中含有针对IgA Fab段的抗体。
J Immunol. 1987 Apr 1;138(7):2244-8.
8
Three M-components IgA lambda + IgG kappa n + IgG kappa h in one patient (DA): lack of shared idiotypic determinants between IgA and IgG, and the presence of an unusual kappa h chain of 30,000 M.W.一名患者（DA）体内有三种M成分：IgA λ+、IgG κn+、IgG κh：IgA和IgG之间缺乏共同的独特型决定簇，且存在一条分子量为30,000的异常κh链。
J Immunol. 1980 Jul;125(1):213-20.
9
Lung injury after deposition of IgA immune complexes. Requirements for CD18 and L-arginine.IgA免疫复合物沉积后的肺损伤。CD18和L-精氨酸的需求。
J Immunol. 1992 May 15;148(10):3086-92.
10
Immunoglobulin A: Fc(alpha)RI interactions induce neutrophil migration through release of leukotriene B4.免疫球蛋白A：Fc(α)RI相互作用通过白三烯B4的释放诱导中性粒细胞迁移。
Gastroenterology. 2009 Dec;137(6):2018-29.e1-3. doi: 10.1053/j.gastro.2009.06.047. Epub 2009 Jun 23.

引用本文的文献

1
Inhibition of formylmethionyl-leucyl-phenylalanine-stimulated neutrophil chemiluminescence by human immunoglobulin A paraproteins.人免疫球蛋白A副蛋白对甲酰甲硫氨酰-亮氨酰-苯丙氨酸刺激的中性粒细胞化学发光的抑制作用
Infect Immun. 1981 Dec;34(3):864-70. doi: 10.1128/iai.34.3.864-870.1981.
2
Inhibition of neutrophil migration by serum IgA from patients with IgA nephropathy.IgA肾病患者血清IgA对中性粒细胞迁移的抑制作用。
Clin Exp Immunol. 1982 Sep;49(3):709-16.
3
In vitro monocyte maturation in squamous-cell carcinoma of the lung: influence of humoral factors.肺鳞状细胞癌中单核细胞的体外成熟：体液因子的影响
Br J Cancer. 1982 Apr;45(4):522-30. doi: 10.1038/bjc.1982.88.
4
Characterization of the IgA receptor from human polymorphonuclear leucocytes.人多形核白细胞IgA受体的特性分析。
Immunology. 1988 Jun;64(2):201-5.
5
Selective immunoglobulin M deficiency associated with disseminated molluscum contagiosum.与播散性传染性软疣相关的选择性免疫球蛋白M缺乏症
Eur J Pediatr. 1986 Apr;145(1-2):99-103. doi: 10.1007/BF00441866.
6
The specificity of the human neutrophil IgA receptor (Fc alpha R) determined by measurement of chemiluminescence induced by serum or secretory IgA1 or IgA2.通过测量血清、分泌型IgA1或IgA2诱导的化学发光来确定人类中性粒细胞IgA受体（FcαR）的特异性。
Immunology. 1990 Nov;71(3):328-34.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
A new supporting medium for preparative electrophoresis.一种用于制备电泳的新型支持介质。
Scand J Clin Lab Invest. 1960;12:33-7.
3
Serum opsonin, bacteria, and polymorphonuclear leukocyte interactions in subacute bacterial endocarditis. Anti-gamma-globulin factors and their interaction with specific opsonins.亚急性细菌性心内膜炎中血清调理素、细菌及多形核白细胞的相互作用。抗γ球蛋白因子及其与特异性调理素的相互作用。
J Clin Invest. 1968 May;47(5):1109-20. doi: 10.1172/JCI105800.
4
Chemotaxis of polymorphonuclear leukocytes from patients with rheumatoid arthritis.类风湿性关节炎患者多形核白细胞的趋化性。
J Clin Invest. 1971 Dec;50(12):2541-9. doi: 10.1172/JCI106754.
5
Defective granulocyte chemotaxis in the Chediak-Higashi syndrome.切迪阿克-希加希综合征中粒细胞趋化性缺陷。
J Clin Invest. 1971 Dec;50(12):2645-52. doi: 10.1172/JCI106765.
6
Interactions of the complement system with endotoxic lipopolysaccharide. Generation of a factor chemotactic for polymorphonuclear leukocytes.补体系统与内毒素脂多糖的相互作用。多形核白细胞趋化因子的产生。
J Exp Med. 1968 Aug 1;128(2):259-75. doi: 10.1084/jem.128.2.259.
7
The release of granule enzymes from human neutrophils stimulated by aggregated immunoglobulins of different classes and subclasses.不同类别和亚类的聚集免疫球蛋白刺激人中性粒细胞后颗粒酶的释放。
J Immunol. 1972 Dec;109(6):1182-92.
8
Cytophilic properties of IgA to human neutrophils.免疫球蛋白A对人中性粒细胞的亲细胞特性。
Adv Exp Med Biol. 1974;45(0):67-74. doi: 10.1007/978-1-4613-4550-3_8.
9
Immunoglobulins cytophilic for human lymphocytes, monocytes, and neutrophils.对人淋巴细胞、单核细胞和中性粒细胞嗜细胞性的免疫球蛋白。
J Clin Invest. 1975 Feb;55(2):368-76. doi: 10.1172/JCI107940.
10
Suppression of leukocyte chemotaxis by human IgA myeloma components.人IgA骨髓瘤成分对白细胞趋化性的抑制作用。
J Exp Med. 1976 Nov 2;144(5):1227-42. doi: 10.1084/jem.144.5.1227.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验