IgA可溶性免疫复合物对中性粒细胞趋化作用的抑制效应。

Suppressive effect of IgA soluble immune complexes on neutrophil chemotaxis.

作者信息

Ito S, Mikawa H, Shinomiya K, Yoshida T

出版信息

Clin Exp Immunol. 1979 Sep;37(3):436-40.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537781/

Abstract

The effect of IgA and IgG soluble immune complexes (SIC) on neutrophil chemotaxis was investigated. Six types of SIC were prepared from kappa-type IgA and IgG myeloma proteins: IgA-anti-kappa chain antibody SIC in IgA excess, IgA-anti-kappa chain antibody in SIC in anti-kappa chain antibody excess, IgA-anti-alpha chain antibody SIC in IgA excess, IgG-anti-kappa chain antibody SIC in IgG excess, IgG-anti-kappa chain antibody SIC in anti-kappa chain antibody excess, and IgG-anti-gamma chain antibody SIC in IgG excess. Three types of IgA SIC had a marked suppressive effect on neutrophil chemotaxis, while IgG SIC, free IgA, free anti-kappa chain antibody, and free anti-gamma chain antibody showed no inhibitory activity. This suppressive effect on neutrophil chemotaxis caused specifically by polymerized IgA was a cell-directed one and was expressed in a concentration dependent manner.

摘要

研究了IgA和IgG可溶性免疫复合物（SIC）对中性粒细胞趋化性的影响。由κ型IgA和IgG骨髓瘤蛋白制备了六种类型的SIC：IgA过量的IgA-抗κ链抗体SIC、抗κ链抗体过量的IgA-抗κ链抗体SIC、IgA过量的IgA-抗α链抗体SIC、IgG过量的IgG-抗κ链抗体SIC、抗κ链抗体过量的IgG-抗κ链抗体SIC以及IgG过量的IgG-抗γ链抗体SIC。三种类型的IgA SIC对中性粒细胞趋化性有显著的抑制作用，而IgG SIC、游离IgA、游离抗κ链抗体和游离抗γ链抗体均无抑制活性。这种由聚合IgA特异性引起的对中性粒细胞趋化性的抑制作用是细胞定向的，并以浓度依赖的方式表现出来。

相似文献

1

Suppressive effect of IgA soluble immune complexes on neutrophil chemotaxis.

Clin Exp Immunol. 1979 Sep;37(3):436-40.

2

Suppressive effect of IgE soluble immune complex on neutrophil chemotaxis.

Clin Exp Immunol. 1983 Feb;51(2):407-12.

3

Three M components IgA lambda, + IgG kappa n + IgG kappa h in one patient. II. Structurally different kappa n and kappa h chains associated with H(gamma) chains sharing idiotypic determinants.

J Immunol. 1982 Oct;129(4):1519-24.

4

Role of beta 1, beta 2 integrins and ICAM-1 in lung injury after deposition of IgG and IgA immune complexes.

J Immunol. 1993 Mar 15;150(6):2407-17.

5

Modulation of the murine immune response to human IgG by complexing with monoclonal antibodies. I. Antibody responses to determinants on the constant region of light chains and gamma chains.

Immunology. 1987 Sep;62(1):1-6.

6

Contrasting roles for tumor necrosis factor in the pathogeneses of IgA and IgG immune complex lung injury.

Am J Pathol. 1991 Mar;138(3):581-90.

7

Normal human sera contain antibodies directed at Fab of IgA.

J Immunol. 1987 Apr 1;138(7):2244-8.

8

Three M-components IgA lambda + IgG kappa n + IgG kappa h in one patient (DA): lack of shared idiotypic determinants between IgA and IgG, and the presence of an unusual kappa h chain of 30,000 M.W.

J Immunol. 1980 Jul;125(1):213-20.

9

Lung injury after deposition of IgA immune complexes. Requirements for CD18 and L-arginine.

J Immunol. 1992 May 15;148(10):3086-92.

10

Immunoglobulin A: Fc(alpha)RI interactions induce neutrophil migration through release of leukotriene B4.

Gastroenterology. 2009 Dec;137(6):2018-29.e1-3. doi: 10.1053/j.gastro.2009.06.047. Epub 2009 Jun 23.

引用本文的文献

1

Inhibition of formylmethionyl-leucyl-phenylalanine-stimulated neutrophil chemiluminescence by human immunoglobulin A paraproteins.

Infect Immun. 1981 Dec;34(3):864-70. doi: 10.1128/iai.34.3.864-870.1981.

2

Inhibition of neutrophil migration by serum IgA from patients with IgA nephropathy.

Clin Exp Immunol. 1982 Sep;49(3):709-16.

3

In vitro monocyte maturation in squamous-cell carcinoma of the lung: influence of humoral factors.

Br J Cancer. 1982 Apr;45(4):522-30. doi: 10.1038/bjc.1982.88.

4

Characterization of the IgA receptor from human polymorphonuclear leucocytes.

Immunology. 1988 Jun;64(2):201-5.

5

Selective immunoglobulin M deficiency associated with disseminated molluscum contagiosum.

Eur J Pediatr. 1986 Apr;145(1-2):99-103. doi: 10.1007/BF00441866.

6

The specificity of the human neutrophil IgA receptor (Fc alpha R) determined by measurement of chemiluminescence induced by serum or secretory IgA1 or IgA2.

Immunology. 1990 Nov;71(3):328-34.

本文引用的文献

1

Protein measurement with the Folin phenol reagent.

J Biol Chem. 1951 Nov;193(1):265-75.

2

A new supporting medium for preparative electrophoresis.

Scand J Clin Lab Invest. 1960;12:33-7.

3

Serum opsonin, bacteria, and polymorphonuclear leukocyte interactions in subacute bacterial endocarditis. Anti-gamma-globulin factors and their interaction with specific opsonins.

J Clin Invest. 1968 May;47(5):1109-20. doi: 10.1172/JCI105800.

4

Chemotaxis of polymorphonuclear leukocytes from patients with rheumatoid arthritis.

J Clin Invest. 1971 Dec;50(12):2541-9. doi: 10.1172/JCI106754.

5

Defective granulocyte chemotaxis in the Chediak-Higashi syndrome.

J Clin Invest. 1971 Dec;50(12):2645-52. doi: 10.1172/JCI106765.

6

Interactions of the complement system with endotoxic lipopolysaccharide. Generation of a factor chemotactic for polymorphonuclear leukocytes.

J Exp Med. 1968 Aug 1;128(2):259-75. doi: 10.1084/jem.128.2.259.

7

The release of granule enzymes from human neutrophils stimulated by aggregated immunoglobulins of different classes and subclasses.

J Immunol. 1972 Dec;109(6):1182-92.

8

Cytophilic properties of IgA to human neutrophils.

Adv Exp Med Biol. 1974;45(0):67-74. doi: 10.1007/978-1-4613-4550-3_8.

9

Immunoglobulins cytophilic for human lymphocytes, monocytes, and neutrophils.

J Clin Invest. 1975 Feb;55(2):368-76. doi: 10.1172/JCI107940.

10

Suppression of leukocyte chemotaxis by human IgA myeloma components.

J Exp Med. 1976 Nov 2;144(5):1227-42. doi: 10.1084/jem.144.5.1227.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。