Coughlin C T, Wong T Z, Strohbehn J W, Colacchio T A, Sutton J E, Belch R Z, Douple E B
Int J Radiat Oncol Biol Phys. 1985 Sep;11(9):1673-8. doi: 10.1016/0360-3016(85)90220-2.
Intra-operative placement of 11-gauge nylon catheters into deep-seated unresectable tumors for interstitial brachytherapy permits localized heating of tumors (hyperthermia) using microwave (915 MHz) antennas which are inserted into these catheters. Four preliminary cases are described where epithelial tumors at various sites were implanted with an antenna array and heated for 1 hour, both before and after the iridium-192 brachytherapy. Temperatures were monitored in catheters required for the appropriate radiation dosimetry but not required for the interstitial microwave antenna array hyperthermia (IMAAH) system. Additional thermometry was obtained using nonperturbed fiberoptic thermometry probes inserted into the catheters' housing antennas. No significant complications, such as bleeding or infection, were observed. This approach to cancer therapy is shown to be feasible and it produces controlled, localized hyperthermia, with temperatures of 50 degrees C or more in tumors. This technique may offer a therapeutic option for pelvic, intra-abdominal and head and neck tumors.
术中将11号尼龙导管置入深部不可切除肿瘤以进行组织间近距离放射治疗，可使用插入这些导管的微波（915MHz）天线对肿瘤进行局部加热（热疗）。本文描述了4例初步病例，在不同部位的上皮性肿瘤植入天线阵列，并在铱-192近距离放射治疗前后均加热1小时。在适当的放射剂量测定所需的导管中监测温度，但这些导管并非组织间微波天线阵列热疗（IMAAH）系统所必需。使用插入导管外壳天线的未受干扰的光纤测温探头进行额外的温度测量。未观察到明显的并发症，如出血或感染。这种癌症治疗方法被证明是可行的，它能产生可控的局部热疗，肿瘤温度可达50摄氏度或更高。该技术可能为盆腔、腹腔内及头颈部肿瘤提供一种治疗选择。
