Prevost B, De Cordoue-Rohart S, Mirabel X, Camart J C, Fabre J J, Sozanski J P, Chive M
Centre de Lutte contre le Cancer Oscar Lambret, Lille, France.
Int J Hyperthermia. 1993 May-Jun;9(3):455-62. doi: 10.3109/02656739309005044.
From October 1989 to October 1991, 16 patients (17 tumours) with locally advanced carcinomas of the oral tongue and eight patients with second carcinomas of the base of tongue in previously irradiated areas, have been treated by means of an interstitial hyperthermia-brachytherapy combination in a phase II clinical trial. Each miniature microwave antenna of our hyperthermia system, called HIMCAR, is used both for heating and for thermal measurements by microwave radiometry at 3 and 9 GHz (see Part I). Among these 25 lesions (21 T2, 4 T3), 21 showed a complete response (15/17 locally advanced carcinomas and 6/8 second carcinomas in previously irradiated areas). The toxicity was not severe (less than 10%). A French multicentre phase III study is now under way.
1989年10月至1991年10月，在一项II期临床试验中，对16例（17个肿瘤）局部晚期舌癌患者和8例先前接受过放疗区域的舌根第二原发癌患者采用了间质热疗-近距离放射治疗联合方案。我们的热疗系统名为HIMCAR，其每个微型微波天线都通过3GHz和9GHz的微波辐射测量法用于加热和热测量（见第一部分）。在这25个病灶（21个T2期，4个T3期）中，21个显示完全缓解（17个局部晚期癌中的15个以及先前放疗区域的8个第二原发癌中的6个）。毒性不严重（低于10%）。一项法国多中心III期研究正在进行中。
