Warner A E, Acland H M, Palmer J E, Trumbauer W K
J Am Vet Med Assoc. 1985 Jul 15;187(2):177-9.
An 8-year-old Holstein cow was referred with a history of weight loss, poor milk production, and hyperfibrinoginemia. Laboratory evaluation showed high gamma-glutamyltransferase activity, prolonged sulfobromophthalein clearance half-time, and prolonged prothrombin and partial thromboplastin times. Multiple firm nodules with histologic evidence of bile ductule carcinoma were found on exploratory laparotomy and liver biopsy. Pulmonary and lymph node tumor metastases were extensive. Tumor development in this case could not be associated with any of the known contributing factors in ruminants. This case demonstrates the extensive metastatic potential of this tumor and nonspecific signs with which bovine hepatic disease can be manifested.
一头8岁的荷斯坦奶牛因体重减轻、产奶量低和高纤维蛋白原血症前来就诊。实验室检查显示γ-谷氨酰转移酶活性升高、磺溴酞钠清除半衰期延长、凝血酶原时间和部分凝血活酶时间延长。在剖腹探查和肝脏活检中发现多个坚实的结节，组织学证据显示为小胆管癌。肺和淋巴结肿瘤转移广泛。该病例中的肿瘤发生与反刍动物任何已知的致病因素均无关联。该病例证明了这种肿瘤具有广泛的转移潜能以及牛肝脏疾病可能表现出的非特异性症状。
