Tony Abeer Abdelhady, Kholef Emad Farah Mohammad, Elgendy Dalia B, Shoyb Ahmed
Department of Neuropsychiatry, Faculty of Medicine, Aswan University, Aswan, Egypt.
Department of Clinical Pathology, Faculty of Medicine, Aswan University, Aswan, Egypt.
Cell Mol Neurobiol. 2025 Apr 30;45(1):39. doi: 10.1007/s10571-025-01552-2.
Serum neurofilament light chain (sNfL) is a marker of injury in many chronic neurological Disorders. We assessed NF-L in patients with acute stroke (ischemic or hemorrhagic) and healthy controls and clarified its association with the stroke severity, etiology, and functional outcome. This case-control study was conducted on 85 patients with first-ever acute stroke (ischemic or hemorrhagic) and 85 control subjects. Participants were subjected to through neurological history and examination. Brain imaging was performed after hospital admission. Blood tests were drawn for assessment of serum neurofilament (sNfL) levels at the first day of admission. Compared to healthy controls, our stroke patients either Ischemic or hemorrhagic had increased sNfL levels. Despite not being statistically different, ischemic stroke patients had greater levels than hemorrhagic stroke patients. Higher sNfL levels were associated with higher NIHSS scores and mRS at admission. In patients with ICH, a correlation was observed between sNfL and hematoma volume, hemorrhage location, ventricular extension and mRS. Moreover, an association of sNfL with Ischemic stroke due to large artery atherosclerosis was reported. In the absence of additional predictive variables like age and sex, it may be possible to quantify sNfL in acute plasma samples as a potential indicator of functional prognosis in patients with ischemic and hemorrhagic strokes. To validate sNfL as a biomarker for acute stroke, however, further research involving a larger number of patients is necessary.
血清神经丝轻链（sNfL）是许多慢性神经系统疾病损伤的标志物。我们评估了急性卒中（缺血性或出血性）患者和健康对照者的神经丝轻链（NF-L），并阐明了其与卒中严重程度、病因及功能转归的关系。本病例对照研究纳入了85例首次发生急性卒中（缺血性或出血性）的患者和85例对照者。对参与者进行了全面的神经病史询问和检查。入院后进行了脑部影像学检查。入院第一天抽取血样以评估血清神经丝（sNfL）水平。与健康对照者相比，我们的缺血性或出血性卒中患者的sNfL水平均升高。尽管差异无统计学意义，但缺血性卒中患者的sNfL水平高于出血性卒中患者。入院时较高的sNfL水平与较高的美国国立卫生研究院卒中量表（NIHSS）评分和改良Rankin量表（mRS）相关。在脑出血（ICH）患者中，观察到sNfL与血肿体积、出血部位、脑室扩展及mRS之间存在相关性。此外，还报道了sNfL与大动脉粥样硬化所致缺血性卒中之间的关联。在缺乏年龄和性别等其他预测变量的情况下，有可能在急性血浆样本中对sNfL进行定量分析，作为缺血性和出血性卒中患者功能预后的潜在指标。然而，为验证sNfL作为急性卒中生物标志物的作用，还需要开展涉及更多患者的进一步研究。
