Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing 400042, China.
Dis Markers. 2022 May 3;2022:5236080. doi: 10.1155/2022/5236080. eCollection 2022.
To explore associations of serum neurofilament light chain (sNfL) at admission with clinical deficits and the long-term prognosis of acute ischaemic stroke (AIS).
We recruited 110 AIS patients with serum sampled at hospital arrival. The concentrations of sNfL were detected by a Simoa HD-1 analyser. We first investigated the determinants of sNfL levels at admission within the study population. Associations of sNfL levels with National Institutes of Health Stroke Scale (NIHSS) scores and modified Rankin Scale (mRS) scores were then tested. We further divided the patients into revascularized and nonrevascularized groups, and the associations of sNfL levels with NIHSS and mRS scores were assessed in these subgroups.
Age, sex, stroke history, and the time between the onset of illness and arrival at the hospital were independent influencing factors of sNfL levels within the study population. The sNfL levels at admission were correlated with the NIHSS scores 7 days after stroke ( = 0.004) across all subjects but showed no correlation with the NIHSS scores at admission ( = 0.293) or the mRS scores 6 months after stroke ( = 0.065). Further analysis revealed that in the nonrevascularized group of AIS patients, the sNfL levels at admission were positively correlated with NIHSS scores (NIHSS at admission, = 0.005; NIHSS 7 days after stroke, = 0.003) and negatively correlated with mRS scores ( = 0.011).
sNfL levels at admission could be a potential biomarker for predicting clinical deficits and prognosis in the natural course of AIS.
探讨入院时血清神经丝轻链（sNfL）与急性缺血性脑卒中（AIS）患者临床缺损及长期预后的相关性。
我们招募了 110 名 AIS 患者，在入院时采集了血清样本。采用 Simoa HD-1 分析仪检测 sNfL 浓度。首先，我们在研究人群中调查了入院时 sNfL 水平的决定因素。然后，检测 sNfL 水平与美国国立卫生研究院卒中量表（NIHSS）评分和改良 Rankin 量表（mRS）评分之间的相关性。进一步将患者分为再通组和未再通组，并在这些亚组中评估 sNfL 水平与 NIHSS 和 mRS 评分之间的相关性。
在研究人群中，年龄、性别、卒中史以及发病到入院的时间是 sNfL 水平的独立影响因素。入院时的 sNfL 水平与所有患者卒中后 7 天的 NIHSS 评分相关（ = 0.004），但与入院时的 NIHSS 评分（ = 0.293）或卒中后 6 个月的 mRS 评分（ = 0.065）无关。进一步分析显示，在 AIS 患者的未再通组中，入院时的 sNfL 水平与 NIHSS 评分呈正相关（入院时 NIHSS， = 0.005；卒中后 7 天 NIHSS， = 0.003），与 mRS 评分呈负相关（ = 0.011）。
入院时的 sNfL 水平可能是预测 AIS 自然病程中临床缺损和预后的潜在生物标志物。
