Tiotiu Angelica, Braido Fulvio, Kowal Krysztof, Fogelbach Guillermo Guidos, Neto Herberto Chong, Ivancevich Juan Carlos, Muti Daniela, Gonzalez-Barcala Francisco-Javier, Steiropoulos Paschalis, Novakova Silviya, Nedeva Denislava, Novakova Plamena, Mihaicuta Stefan, Bernstein Jonathan, Yorgancioglu Arzu, Santus Pierachille, Bikov Andras, Canonica Giorgio Walter, Pilette Charles
Department of Pneumology, University Hospital Saint-Luc, 10 Avenue Hippocrate, 1200, Brussels, Belgium.
Pole Pneumology, ENT, and Dermatology - LUNS, Institute of Experimental and Clinical Research (IREC), UCLouvain, Brussels, Belgium.
Clin Rev Allergy Immunol. 2025 Apr 30;68(1):45. doi: 10.1007/s12016-025-09055-0.
Despite house dust mite (HDM)-allergy is the most frequent in the world, no standard questionnaire exists to help physicians in their clinical practice for screening patients with this possible diagnosis. The objective of this survey was to develop a questionnaire that could be used to identify patients with suspicion of HDM-allergy. The survey was conducted using the Delphi methodology. Nineteen international experts in allergology constituted the scientific board who established the items included in the first version of the questionnaire, defined the criteria of the selection for the next steps, and validated the final questionnaire and its interpretation. The initial version of the questionnaire included 15 items. For each item, five answers were suggested graduated by scores from "no importance" to "very high importance." The predefined conditions for the item selection after each round were a median score ≥ 7 and > 50% of responses according "high importance" and "very high importance." The electronic survey circulated within the Interasma Scientific Network platform. Eight questions based on the occurrence/worsening of symptoms induced by HDM-allergen exposure meet the survey criteria after the second and the third rounds and were included in the final questionnaire. Binomial answers for each question with 1 point accorded for "Yes" and none for "No" were suggested for the final version with a score ≥ 5 points associated with a high probability for HDM-allergy. By applying the Delphi process, we generated a brief questionnaire with binomial answers, easy to use in clinical practice for screening patients with HDM-allergy.
尽管屋尘螨（HDM）过敏是全球最常见的过敏症，但目前尚无标准问卷可帮助医生在临床实践中筛查可能患有这种疾病的患者。本次调查的目的是开发一种可用于识别疑似HDM过敏患者的问卷。该调查采用德尔菲法进行。19位国际过敏学专家组成了科学委员会，他们确定了问卷第一版中包含的项目，定义了后续步骤的选择标准，并验证了最终问卷及其解释。问卷的初始版本包含15个项目。对于每个项目，提供了五个答案，从“不重要”到“非常重要”按分数分级。每轮后项目选择的预定义条件是中位数得分≥7，且“高重要性”和“非常高重要性”的回答占比>50%。电子调查在Interasma科学网络平台内进行。经过第二轮和第三轮，基于HDM过敏原暴露引起的症状出现/加重的八个问题符合调查标准，并被纳入最终问卷。最终版本建议每个问题采用二项式答案，“是”得1分，“否”不得分，得分≥5分与HDM过敏的高概率相关。通过应用德尔菲法，我们生成了一份简短的二项式答案问卷，便于在临床实践中用于筛查HDM过敏患者。
