Ganguly A K, Afonso A, Girijavallabhan V M, McCombie S
J Antimicrob Chemother. 1985 Jun;15 Suppl C:1-4. doi: 10.1093/jac/15.suppl_c.1.
Sch 34343, a new penem antibiotic, has been synthesized by several routes and found to be highly active against both aerobic and anaerobic Gram-positive and Gram-negative organisms (except Pseudomonas). It has excellent beta-lactamase stability and is bactericidal. The synthetic routes to Sch 34343 and its in-vitro activity compared with other structurally related penems are discussed.
Sch 34343是一种新型青霉烯类抗生素，已通过多种途径合成，发现其对需氧和厌氧革兰氏阳性及革兰氏阴性菌（除假单胞菌外）均具有高度活性。它具有出色的β-内酰胺酶稳定性，且具有杀菌作用。本文讨论了Sch 34343的合成途径及其与其他结构相关青霉烯类抗生素相比的体外活性。
