Dow Emma, Kearney Stephanie, Day Mhairi
Department of Vision Sciences, School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, Scotland, United Kingdom.
https://orcid.org/0009-0002-2470-4953.
Invest Ophthalmol Vis Sci. 2025 Apr 1;66(4):82. doi: 10.1167/iovs.66.4.82.
The risks of developing myopia complications are frequently reported in relative terms, which can be misleading. This study provides absolute risk estimates of visual impairment (VI) from myopia-related diseases.
A critical integrative review provided data on frequency of myopic macular degeneration (MMD), primary open-angle glaucoma (POAG), rhegmatogenous retinal detachment (RRD), and associated VI in predominantly White and East Asian populations. The absolute risks of persons over 40 years of age with no myopia, low myopia (-2.00 D), or high myopia (-6.00 D) developing VI from each myopia-related disease were calculated by multiplying the proportion of each refractive group with the disease by the rate of VI. The sum of the risks of VI from MMD, POAG, and RRD provided an estimate of VI risk from any of these three myopia-related diseases in adults over 40 years old.
VI from MMD, POAG, or RRD combined is expected in 0.4 in 100, 1.4 in 100, and 6.8 in 100 of White persons with no myopia, low myopia, or high myopia, respectively. The same risks in an East Asian population are 0.5 in 100, 2.4 in 100 and 10.3 in 100 in persons with no myopia, low myopia, or high myopia, respectively.
Absolute risks are provided to enable balanced discussions of the future risk that a child may have in developing VI from myopia-related diseases when considering myopia management. These estimates should be put into context using decision tools and balanced statements providing information on the likelihood of both developing VI and not developing VI.
近视并发症发生风险常以相对值报告,这可能会产生误导。本研究提供了与近视相关疾病导致视力损害(VI)的绝对风险估计。
一项关键的综合综述提供了主要为白人和东亚人群中近视性黄斑变性(MMD)、原发性开角型青光眼(POAG)、孔源性视网膜脱离(RRD)及相关视力损害的发生频率数据。通过将各屈光组中患该疾病的比例乘以视力损害发生率,计算40岁以上无近视、低度近视(-2.00 D)或高度近视(-6.00 D)人群因每种与近视相关疾病而发生视力损害的绝对风险。MMD、POAG和RRD导致视力损害的风险总和提供了40岁以上成年人因这三种与近视相关疾病中任何一种而发生视力损害风险的估计值。
在无近视、低度近视或高度近视的白人中,MMD、POAG或RRD合并导致视力损害的预期风险分别为每100人中有0.4人、1.4人及6.8人。在东亚人群中,无近视、低度近视或高度近视者的相应风险分别为每100人中有0.5人、2.4人及10.3人。
提供绝对风险是为了在考虑近视管理时,能对儿童未来因与近视相关疾病而发生视力损害的风险进行平衡讨论。这些估计值应结合决策工具以及提供视力损害发生和未发生可能性信息的平衡声明来理解。