Lu Chunan, Sun Qili, Li Zimo, Wei Yushan, Yu Jialin, Li Shiman, Wang Yansong, Li Kai, Tang Chuqing, Cao Huicheng, Chen Jingle, Liu Qianqian, Liang Xiajun, Zhang Shujiang, Xie Chao, Tang Bin
Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, PR China.
Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, PR China; Shenzhen Middle School, Shenzhen, Guangdong, PR China.
Carbohydr Polym. 2025 Jul 1;359:123562. doi: 10.1016/j.carbpol.2025.123562. Epub 2025 Apr 3.
Wound healing remains a significant clinical challenge, particularly for chronic and non-healing wounds, which impose substantial burdens on patients and healthcare systems. Despite advances in wound care, traditional dressings lack therapeutic properties and can impede the healing process due to their inability to conform to irregular wound geometries and lack of self-healing capabilities. This study addresses these limitations by introducing an innovative, injectable Glycyrrhizic acid ammonium salt/Pectin@Strontium (GAAS/Pec@Sr) hydrogel dressing. The hydrogel is derived from natural ingredients and possesses multifunctional therapeutic properties, including bioabsorbability, self-healing, and the ability to promote blood vessel and collagen regeneration while exhibiting anti-inflammatory and immunomodulatory functions. We developed the GAAS/Pec@Sr hydrogel through a combination of rheological experiments, gene and protein expression studies, and in vivo testing in a rat skin injury model. The GAAS/Pec@Sr hydrogel represents a promising biomaterial for wound healing, offering a novel solution derived entirely from natural products that can significantly contribute to the field of regenerative medicine.
伤口愈合仍然是一个重大的临床挑战，特别是对于慢性和不愈合伤口而言，这些伤口给患者和医疗系统带来了沉重负担。尽管伤口护理取得了进展，但传统敷料缺乏治疗特性，并且由于无法贴合不规则的伤口形状以及缺乏自我愈合能力，可能会阻碍愈合过程。本研究通过引入一种创新的、可注射的甘草酸铵盐/果胶@锶（GAAS/Pec@Sr）水凝胶敷料来解决这些局限性。该水凝胶源自天然成分，具有多功能治疗特性，包括生物可吸收性、自我愈合能力，以及促进血管和胶原蛋白再生的能力，同时还具有抗炎和免疫调节功能。我们通过流变学实验、基因和蛋白质表达研究以及在大鼠皮肤损伤模型中的体内测试相结合的方式开发了GAAS/Pec@Sr水凝胶。GAAS/Pec@Sr水凝胶是一种有前景的用于伤口愈合的生物材料，提供了一种完全源自天然产物的新解决方案，可对再生医学领域做出重大贡献。
