Hubei Engineering Center of Natural Polymers-based Medical Materials, Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, China.
Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, China.
Carbohydr Polym. 2022 Jan 15;276:118718. doi: 10.1016/j.carbpol.2021.118718. Epub 2021 Oct 2.
Developing an efficient and available material for improved cutaneous tissue regeneration is a major challenge in healthcare. Inspired by the concept of moist wound healing, the injectable and self-healing adenine-modified chitosan (AC) hydrogels are designed to significantly accelerate wound healing without the addition of therapeutic drugs. A series of AC derivatives with degree of substitution (DS) ranging from 0.21 to 0.55 were synthesized in aqueous solutions, and the AC hydrogels were prepared by a simple heating/cooling process. AC hydrogels presented good self-healing, low swelling rate capacity, biocompatibility, promote cell proliferation and excellent hemostatic effect. The hydrogels displayed excellent antibacterial activities against gram-negative bacteria, gram-positive bacteria, fungi and drug-resistance bacteria. Moreover, the full-thickness skin defect model experiments showed that AC hydrogels could reduce inflammatory cell infiltration and accelerate wound healing significantly. The hydrogel can shed new light on designing of the multifunctional dressings for wound healing.
开发高效、可用的材料以促进皮肤组织再生是医疗保健领域的一大挑战。受湿性伤口愈合概念的启发，设计了可注射和自修复的腺嘌呤修饰壳聚糖 (AC) 水凝胶，无需添加治疗药物即可显著加速伤口愈合。在水溶液中合成了一系列取代度 (DS) 从 0.21 到 0.55 的 AC 衍生物，并通过简单的加热/冷却过程制备了 AC 水凝胶。AC 水凝胶具有良好的自修复性、低溶胀率、生物相容性、促进细胞增殖和优异的止血效果。水凝胶对革兰氏阴性菌、革兰氏阳性菌、真菌和耐药菌具有优异的抗菌活性。此外，全厚皮肤缺损模型实验表明，AC 水凝胶可显著减少炎症细胞浸润并加速伤口愈合。该水凝胶为伤口愈合的多功能敷料设计提供了新的思路。
