Cai Xiaoli, Zhao Yan, Liu Shuang, Dong Fangru, An Jie, Liu Yanli, Liu Lin
Department of Pathology, Bethune International Peace Hospital, Shijiazhuang, Hebei, 050000, China.
Department of Orthopaedics, Bethune International Peace Hospital, No. 398 Zhongshan West Road, Qiaoxi District, Shijiazhuang, Hebei, 050000, China.
Eur Arch Otorhinolaryngol. 2025 Sep;282(9):4891-4898. doi: 10.1007/s00405-025-09438-1. Epub 2025 Apr 30.
Ceruminous adenomas (CA) are rare neoplasms of the external auditory canal (EAC), and their nonspecific symptoms frequently contribute to diagnostic challenges in clinical practice. By examining the clinical features, diagnostic considerations, and therapeutic approaches for these tumors, the findings aim to improve understanding of these tumors and improve clinical outcomes.
A retrospective analysis was conducted on six individuals diagnosed with CAs of the EAC at a single institution between January 2010 and January 2023. Clinical data, histopathological characteristics, and immunophenotypic findings were reviewed, along with a relevant literature analysis. Of the six cases, three involved simple CAs, one was associated with concurrent adenoid cystic carcinoma, and two exhibited localized areas of high mitotic activity, necessitating vigilant follow-up. No recurrences were observed during the follow-up period. Symptomatically, one patient reported occasional tinnitus, while another presented with ear discharge.
The diagnosis of ceruminous gland tumors requires a multidisciplinary approach, incorporating clinical evaluation, imaging studies, and histopathological examination. CAs of the EAC are uncommon, with reports in the literature indicating a risk of recurrence and potential for malignancy. Surgical management should involve wide excision with wound repair, followed by close postoperative monitoring to ensure early detection of any recurrence.
耵聍腺瘤(CA)是外耳道(EAC)的罕见肿瘤,其非特异性症状常常给临床实践中的诊断带来挑战。通过研究这些肿瘤的临床特征、诊断要点及治疗方法,本研究结果旨在增进对这些肿瘤的了解并改善临床结局。
对2010年1月至2023年1月期间在某单一机构诊断为外耳道耵聍腺瘤的6例患者进行回顾性分析。回顾了临床资料、组织病理学特征及免疫表型结果,并进行了相关文献分析。6例病例中,3例为单纯耵聍腺瘤,1例合并腺样囊性癌,2例出现局部高有丝分裂活性区域,需要密切随访。随访期间未观察到复发情况。症状方面,1例患者报告偶尔耳鸣,另1例有耳溢液。
耵聍腺肿瘤的诊断需要多学科方法,包括临床评估、影像学检查和组织病理学检查。外耳道耵聍腺瘤并不常见,文献报道提示有复发风险及恶变可能。手术治疗应包括广泛切除并修复创面,术后密切监测以确保早期发现任何复发情况。