• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

外耳道耵聍腺瘤的临床病理特征及处理:6例回顾性分析

Clinicopathological characteristics and management of ceruminous adenomas in the external auditory canal: a retrospective analysis of six cases.

作者信息

Cai Xiaoli, Zhao Yan, Liu Shuang, Dong Fangru, An Jie, Liu Yanli, Liu Lin

机构信息

Department of Pathology, Bethune International Peace Hospital, Shijiazhuang, Hebei, 050000, China.

Department of Orthopaedics, Bethune International Peace Hospital, No. 398 Zhongshan West Road, Qiaoxi District, Shijiazhuang, Hebei, 050000, China.

出版信息

Eur Arch Otorhinolaryngol. 2025 Sep;282(9):4891-4898. doi: 10.1007/s00405-025-09438-1. Epub 2025 Apr 30.

DOI:10.1007/s00405-025-09438-1
PMID:40307611
Abstract

BACKGROUND

Ceruminous adenomas (CA) are rare neoplasms of the external auditory canal (EAC), and their nonspecific symptoms frequently contribute to diagnostic challenges in clinical practice. By examining the clinical features, diagnostic considerations, and therapeutic approaches for these tumors, the findings aim to improve understanding of these tumors and improve clinical outcomes.

CASE PRESENTATION

A retrospective analysis was conducted on six individuals diagnosed with CAs of the EAC at a single institution between January 2010 and January 2023. Clinical data, histopathological characteristics, and immunophenotypic findings were reviewed, along with a relevant literature analysis. Of the six cases, three involved simple CAs, one was associated with concurrent adenoid cystic carcinoma, and two exhibited localized areas of high mitotic activity, necessitating vigilant follow-up. No recurrences were observed during the follow-up period. Symptomatically, one patient reported occasional tinnitus, while another presented with ear discharge.

CONCLUSION

The diagnosis of ceruminous gland tumors requires a multidisciplinary approach, incorporating clinical evaluation, imaging studies, and histopathological examination. CAs of the EAC are uncommon, with reports in the literature indicating a risk of recurrence and potential for malignancy. Surgical management should involve wide excision with wound repair, followed by close postoperative monitoring to ensure early detection of any recurrence.

摘要

背景

耵聍腺瘤(CA)是外耳道(EAC)的罕见肿瘤,其非特异性症状常常给临床实践中的诊断带来挑战。通过研究这些肿瘤的临床特征、诊断要点及治疗方法,本研究结果旨在增进对这些肿瘤的了解并改善临床结局。

病例报告

对2010年1月至2023年1月期间在某单一机构诊断为外耳道耵聍腺瘤的6例患者进行回顾性分析。回顾了临床资料、组织病理学特征及免疫表型结果,并进行了相关文献分析。6例病例中,3例为单纯耵聍腺瘤,1例合并腺样囊性癌,2例出现局部高有丝分裂活性区域,需要密切随访。随访期间未观察到复发情况。症状方面,1例患者报告偶尔耳鸣,另1例有耳溢液。

结论

耵聍腺肿瘤的诊断需要多学科方法,包括临床评估、影像学检查和组织病理学检查。外耳道耵聍腺瘤并不常见,文献报道提示有复发风险及恶变可能。手术治疗应包括广泛切除并修复创面,术后密切监测以确保早期发现任何复发情况。

相似文献

1
Clinicopathological characteristics and management of ceruminous adenomas in the external auditory canal: a retrospective analysis of six cases.外耳道耵聍腺瘤的临床病理特征及处理:6例回顾性分析
Eur Arch Otorhinolaryngol. 2025 Sep;282(9):4891-4898. doi: 10.1007/s00405-025-09438-1. Epub 2025 Apr 30.
2
Challenges in Achieving a Definitive Diagnosis of External Auditory Canal Squamous Cell Carcinoma.实现外耳道鳞状细胞癌明确诊断的挑战。
Otol Neurotol. 2025 Sep 1;46(8):972-977. doi: 10.1097/MAO.0000000000004559. Epub 2025 Jun 2.
3
Prescription of Controlled Substances: Benefits and Risks管制药品的处方:益处与风险
4
Ear drops for the removal of ear wax.用于清除耳垢的滴耳剂。
Cochrane Database Syst Rev. 2018 Jul 25;7(7):CD012171. doi: 10.1002/14651858.CD012171.pub2.
5
Transcanal endoscopic ear surgery for pediatric external auditory canal cholesteatoma.经耳道内镜下小儿外耳道胆脂瘤手术
Int J Pediatr Otorhinolaryngol. 2025 Aug;195:112426. doi: 10.1016/j.ijporl.2025.112426. Epub 2025 Jun 9.
6
Avoiding misdiagnosis in ceruminous gland tumours.避免耵聍腺肿瘤的误诊。
Auris Nasus Larynx. 2003 Aug;30(3):287-90. doi: 10.1016/s0385-8146(03)00055-5.
7
Adenoid cystic carcinoma of ceruminous gland: a case report.耵聍腺腺样囊性癌:一例报告
Indian J Pathol Microbiol. 2006 Oct;49(4):587-9.
8
Ceruminous adenomas: a clinicopathologic study of 41 cases with a review of the literature.耵聍腺瘤:41例临床病理研究并文献复习
Am J Surg Pathol. 2004 Mar;28(3):308-18. doi: 10.1097/00000478-200403000-00003.
9
Tumors arising from the glandular structures of the external auditory canal.起源于外耳道腺性结构的肿瘤。
Laryngoscope. 1983 Mar;93(3):326-40. doi: 10.1288/00005537-198303000-00016.
10
Use of endoanal ultrasound for reducing the risk of complications related to anal sphincter injury after vaginal birth.使用经肛门超声降低阴道分娩后肛门括约肌损伤相关并发症的风险。
Cochrane Database Syst Rev. 2015 Oct 29;2015(10):CD010826. doi: 10.1002/14651858.CD010826.pub2.

本文引用的文献

1
[Adenoid cystic carcinoma of the ceruminous glands].[耵聍腺腺样囊性癌]
Pathologie (Heidelb). 2024 May;45(3):162-163. doi: 10.1007/s00292-024-01309-6. Epub 2024 Feb 19.
2
Ceruminous adenoma of the external auditory canal: 9 cases series with imaging and pathologic findings.外耳道耵聍腺瘤:9例系列病例的影像学和病理表现
Front Oncol. 2023 Jul 6;13:1041282. doi: 10.3389/fonc.2023.1041282. eCollection 2023.
3
Ceruminous Adenoma: A Rare Mass that Impair Hearing.耵聍腺瘤:一种影响听力的罕见肿物。
Medeni Med J. 2021;36(3):270-275. doi: 10.5222/MMJ.2021.36974. Epub 2021 Sep 30.
4
Ceruminous Neoplasms of the Ear.耳部耵聍瘤
Head Neck Pathol. 2018 Sep;12(3):350-361. doi: 10.1007/s12105-018-0909-3. Epub 2018 Aug 1.
5
[Combined tumor of ceruminous gland origin in the external auditory canal--a histopathological and immunohistochemical study].[外耳道耵聍腺源性复合肿瘤——组织病理学和免疫组织化学研究]
Otolaryngol Pol. 2010 Nov-Dec;64(6):385-7. doi: 10.1016/S0030-6657(10)70592-8.
6
Adenoma of the ceruminous gland.
Otolaryngol Head Neck Surg. 2010 Sep;143(3):459-60. doi: 10.1016/j.otohns.2010.05.016.
7
Ceruminous gland carcinomas: a clinicopathologic and immunophenotypic study of 17 cases.耵聍腺癌:17例临床病理及免疫表型研究
Head Neck Pathol. 2009 Mar;3(1):1-17. doi: 10.1007/s12105-008-0095-9. Epub 2008 Dec 3.
8
Ceruminous adenoma mimicking furunculosis in the external auditory canal.外耳道内酷似疖病的耵聍腺瘤。
Eur Arch Otorhinolaryngol. 2007 Mar;264(3):223-5. doi: 10.1007/s00405-006-0166-z. Epub 2006 Oct 3.
9
Ceruminous adenomas: a clinicopathologic study of 41 cases with a review of the literature.耵聍腺瘤:41例临床病理研究并文献复习
Am J Surg Pathol. 2004 Mar;28(3):308-18. doi: 10.1097/00000478-200403000-00003.
10
Ceruminous gland tumour (a case report).耵聍腺肿瘤(病例报告)
J Laryngol Otol. 1988 Apr;102(4):346-9. doi: 10.1017/s002221510010492x.