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斯氏梭菌：参与胆汁酸和类固醇代谢的哺乳动物肠道关键物种的历史与当前展望

Clostridium scindens: history and current outlook for a keystone species in the mammalian gut involved in bile acid and steroid metabolism.

作者信息

Daniel Steven L, Ridlon Jason M

机构信息

Department of Biological Sciences, Eastern Illinois University, Charleston, IL 61920, United States.

Department of Animal Sciences, University of Illinois Urbana-Champaign, Urbana, IL 61801, United States.

出版信息

FEMS Microbiol Rev. 2025 Jan 14;49. doi: 10.1093/femsre/fuaf016.

DOI:10.1093/femsre/fuaf016
PMID:40307670
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12065433/
Abstract

Clostridium scindens is a keystone bacterial species in the mammalian gut that, while low in abundance, has a significant impact on bile acid and steroid metabolism. Numerous studies indicate that the two most studied strains of C. scindens (i.e. ATCC 35704 and VPI 12708) are important for a myriad of physiological processes in the host. We focus on both historical and current microbiological and molecular biology work on the Hylemon-Björkhem pathway and the steroid-17,20-desmolase pathway that were first discovered in C. scindens. Our most recent analysis now calls into question whether strains currently defined as C. scindens represent two separate taxonomic groups. Future directions include developing genetic tools to further explore the physiological role of bile acid and steroid metabolism by strains of C. scindens and the causal role of these pathways in host physiology and disease.

摘要

梭状芽孢杆菌是哺乳动物肠道中的一种关键细菌物种，虽然其丰度较低，但对胆汁酸和类固醇代谢有重大影响。大量研究表明，梭状芽孢杆菌的两种研究最多的菌株（即ATCC 35704和VPI 12708）对宿主的众多生理过程很重要。我们关注最早在梭状芽孢杆菌中发现的Hylemon-Björkhem途径和类固醇-17,20-裂解酶途径的历史和当前微生物学及分子生物学研究工作。我们最近的分析现在对目前定义为梭状芽孢杆菌的菌株是否代表两个不同的分类群提出了质疑。未来的方向包括开发遗传工具，以进一步探索梭状芽孢杆菌菌株对胆汁酸和类固醇代谢的生理作用，以及这些途径在宿主生理和疾病中的因果作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/81c4c042dfe7/fuaf016fig12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/9552b38b41c9/fuaf016fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/72c3a89c37ff/fuaf016fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/3563d032c70d/fuaf016fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/1b863d9acc70/fuaf016fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/4ba0c26a3f00/fuaf016fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/86f17b3f7672/fuaf016fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/c85d49f144ad/fuaf016fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/11bc8f70a54d/fuaf016fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/a5acf89479ca/fuaf016fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/b4b5db6f033a/fuaf016fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/1bd62dab26e1/fuaf016fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/81c4c042dfe7/fuaf016fig12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/9552b38b41c9/fuaf016fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/72c3a89c37ff/fuaf016fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/3563d032c70d/fuaf016fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/1b863d9acc70/fuaf016fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/4ba0c26a3f00/fuaf016fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/86f17b3f7672/fuaf016fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/c85d49f144ad/fuaf016fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/11bc8f70a54d/fuaf016fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/a5acf89479ca/fuaf016fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/b4b5db6f033a/fuaf016fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/1bd62dab26e1/fuaf016fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2819/12065433/81c4c042dfe7/fuaf016fig12.jpg

相似文献

[1]
Clostridium scindens: history and current outlook for a keystone species in the mammalian gut involved in bile acid and steroid metabolism.

FEMS Microbiol Rev. 2025-1-14

[2]
: an endocrine keystone species in the mammalian gut.

bioRxiv. 2024-8-24

[3]
Microbiome and metabolome association network analysis identifies as a stronger keystone genus candidate than in the gut of common marmosets.

mSystems. 2025-7-7

[4]
7β-Hydroxysteroid dehydratase Hsh3 eliminates the 7-hydroxy group of the bile salt ursodeoxycholate during degradation by sp. strain Chol11 and other .

Appl Environ Microbiol. 2025-6-18

[5]
A relationship between body size and the gut microbiome suggests a conservation strategy.

Microbiol Spectr. 2025-7

[6]
Clostridium scindens ATCC 35704: Integration of Nutritional Requirements, the Complete Genome Sequence, and Global Transcriptional Responses to Bile Acids.

Appl Environ Microbiol. 2019-3-22

[7]
SeHCAT [tauroselcholic (selenium-75) acid] for the investigation of bile acid malabsorption and measurement of bile acid pool loss: a systematic review and cost-effectiveness analysis.

Health Technol Assess. 2013-12

[8]
Adjunctive steroid therapy versus antibiotics alone for acute endophthalmitis after intraocular procedure.

Cochrane Database Syst Rev. 2017-2-22

[9]
The interplay of gut microbiota and intestinal motility in gastrointestinal function.

J Smooth Muscle Res. 2025

[10]
Adjunctive steroid therapy versus antibiotics alone for acute endophthalmitis after intraocular procedure.

Cochrane Database Syst Rev. 2022-6-6

本文引用的文献

[1]
Pangenome Analysis of : A Collection of Diverse Bile Acid- and Steroid-Metabolizing Commensal Gut Bacterial Strains.

Microorganisms. 2025-4-9

[2]
An expanded metabolic pathway for androgen production by commensal bacteria.

Nat Microbiol. 2025-5

[3]
Genome sequences of nine strains isolated from human feces.

Microbiol Resour Announc. 2024-12-12

[4]
5α-reduction of epitestosterone is catalysed by human SRD5A1 and SRD5A2 and increases androgen receptor transactivation.

J Steroid Biochem Mol Biol. 2024-7

[5]
BaiJ and BaiB are key enzymes in the chenodeoxycholic acid 7α-dehydroxylation pathway in the gut microbe ATCC 35704.

Gut Microbes. 2024

[6]
Bile salt hydrolase acyltransferase activity expands bile acid diversity.

Nature. 2024-2

[7]
Advancements in Novel Live Biotherapeutic Products for Clostridioides difficile Infection Prevention.

Clin Infect Dis. 2023-12-5

[8]
Complete genome sequence of the archetype bile acid 7α-dehydroxylating bacterium, VPI12708, isolated from human feces, circa 1980.

Microbiol Resour Announc. 2023-9-19

[9]
The Hylemon-Björkhem pathway of bile acid 7-dehydroxylation: history, biochemistry, and microbiology.

J Lipid Res. 2023-8

[10]
Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site.

J Biol Chem. 2023-3

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