Dong Zhiyu, Wang Xiaomei, Xuan Liqian, Wang Junwen, Zhan Tingting, Chen Ying, Xu Shuchang, Ji Danian
Department of Gastrointestinal Endoscopy, Huadong Hospital, Fudan University, Shanghai, China.
Department of Gastroenterology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
BMC Gastroenterol. 2025 Apr 30;25(1):321. doi: 10.1186/s12876-025-03919-7.
Childhood trauma and negative events during adulthood were associated with the symptom severity of irritable bowel syndrome (IBS). However, the interaction effect of these negative events on IBS remains poorly understood.
70 healthy individuals who completed Childhood Trauma Questionnaire (CTQ) and Life Event Scale (LES) and 88 IBS patients, diagnosed based on the Rome IV criteria, who completed CTQ, LES, IBS-Quality of Life (IBS-QOL), and IBS-Severity Scoring System (IBS-SSS) were retrospectively included. Logistic and linear regression analyses were used to investigate the interaction effect between childhood trauma and negative events during adulthood on IBS.
Female sex, childhood emotional abuse and neglect, and negative events during adulthood were associated with a higher prevalence of IBS. In IBS patients, childhood emotional abuse and neglect, as well as negative events during adulthood, were independently associated with more severe symptoms and worse quality of life. A significant interaction effect between childhood emotional trauma and negative events during adulthood was observed in IBS severity and quality of life, though no interaction effect was found in IBS development. Subsequent analyses revealed that the effect of negative events during adulthood on IBS severity and quality of life increased in IBS patients with childhood emotional trauma (IBS-SSS, β = 5.75, p < 0.001; IBS-QOL, β = 2.1, p < 0.001) compared with those without (IBS-SSS, β = 3.23, p < 0.001; IBS-QOL, β = 0.69, p = 0.011).
Childhood emotional trauma and negative events during adulthood were associated with IBS development, higher IBS severity, and worse quality of life. Furthermore, childhood emotional trauma increased the negative effect of negative events during adulthood on IBS severity and quality of life.
童年创伤和成年期负面事件与肠易激综合征（IBS）的症状严重程度相关。然而，这些负面事件对IBS的交互作用仍知之甚少。
回顾性纳入70名完成儿童期创伤问卷（CTQ）和生活事件量表（LES）的健康个体，以及88名根据罗马IV标准诊断的IBS患者，这些患者完成了CTQ、LES、IBS生活质量量表（IBS-QOL）和IBS严重程度评分系统（IBS-SSS）。采用逻辑回归和线性回归分析来研究童年创伤与成年期负面事件对IBS的交互作用。
女性、童年期情感虐待和忽视以及成年期负面事件与IBS的较高患病率相关。在IBS患者中，童年期情感虐待和忽视以及成年期负面事件与更严重的症状和更差的生活质量独立相关。在IBS严重程度和生活质量方面观察到童年期情感创伤与成年期负面事件之间存在显著的交互作用，尽管在IBS发病方面未发现交互作用。随后的分析显示，与没有童年期情感创伤的IBS患者相比，有童年期情感创伤的IBS患者中，成年期负面事件对IBS严重程度和生活质量的影响更大（IBS-SSS，β = 5.75，p < 0.001；IBS-QOL，β = 2.1，p < 0.001），而无童年期情感创伤的患者中（IBS-SSS，β = 3.23，p < 0.001；IBS-QOL，β = 0.69，p = 0.011）。
童年期情感创伤和成年期负面事件与IBS发病、更高的IBS严重程度和更差的生活质量相关。此外，童年期情感创伤增加了成年期负面事件对IBS严重程度和生活质量的负面影响。
