口腔苔藓样黏膜炎临床特征与全身疾病潜在联系的研究

Study on the potential links between clinical features of oral lichenoid mucositis and systemic diseases.

作者信息

Wang Peilin, Yan Peipei, Zhang Yihang, Li Yanjie, Du Fei, Zhang Miao, Wang Rong, Yan Yingbing, Zhang Hongkai, Chen Ruiyang, Liu Chenlu

机构信息

Department of Oral Mucosal Diseases, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, 300041, China.

Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, 300041, China.

出版信息

BMC Oral Health. 2025 Apr 30;25(1):669. doi: 10.1186/s12903-025-06024-z.

DOI:10.1186/s12903-025-06024-z

PMID:40307788

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12044897/

Abstract

OBJECTIVE

This study aimed to analyze the clinical characteristics of oral lichenoid disease and investigate its potential association with systemic diseases.

METHODS

This study was a retrospective cross-sectional analysis. The study comprised 116 patients who had been diagnosed with oral lichenoid disease, including 70 with oral lichen planus and 46 with lichenoid lesions. The study meticulously documented the distribution and types of lesions in oral lichenoid disease patients.

RESULTS

The average age was 46 years, with females representing 69.8% and males 30.2%. The prevalence of major systemic diseases among these patients was notable: thyroid disorders were observed in 64.7%, dyslipidemia in 44.0%, hyperuricemia in 36.2%, hypertension in 28.5%, and diabetes in 21.6%. Significant associations were found between specific lesion sites and systemic diseases. Network-like lesions in the gingival-buccal groove were highly correlated with thyroid disorders (P < 0.000). Lichenoid lesions on the lips were significantly associated with dyslipidemia (P < 0.002). Furthermore, lesions on both the dorsal (P < 0.000) and ventral (P < 0.038) surfaces of the tongue, particularly patchy lesions on the dorsal surface, showed a strong association with hyperuricemia.

CONCLUSION

These findings indicated a significant correlation between the clinical manifestations of oral lichenoid disease and systemic conditions such as thyroid disorders, dyslipidemia, and hyperuricemia.

摘要

目的

本研究旨在分析口腔苔藓样病的临床特征，并探讨其与全身性疾病的潜在关联。

方法

本研究为回顾性横断面分析。该研究纳入了116例被诊断为口腔苔藓样病的患者，其中包括70例口腔扁平苔藓患者和46例苔藓样病变患者。该研究详细记录了口腔苔藓样病患者病变的分布和类型。

结果

平均年龄为46岁，女性占69.8%，男性占30.2%。这些患者中主要全身性疾病的患病率值得注意：甲状腺疾病的患病率为64.7%，血脂异常为44.0%，高尿酸血症为36.2%，高血压为28.5%，糖尿病为21.6%。在特定病变部位与全身性疾病之间发现了显著关联。龈颊沟处的网状病变与甲状腺疾病高度相关（P < 0.000）。唇部的苔藓样病变与血脂异常显著相关（P < 0.002）。此外，舌背（P < 0.000）和舌腹（P < 0.038）表面的病变，特别是舌背的斑片状病变，与高尿酸血症有很强的关联。