Semel Maya, Lukasiewicz Cole, Hepple Russell T
Department of Physiology & Aging, University of Florida, Gainesville, FL.
Department of Physical Therapy, University of Florida, Gainesville, FL.
Exerc Sport Sci Rev. 2025 Jul 1;53(3):101-109. doi: 10.1249/JES.0000000000000364. Epub 2025 May 1.
Our Perspective for Progress highlights sex differences in skeletal muscle mitochondrial function that evolve with aging, with an influence of denervation emerging in advanced age. Gaps include knowledge about mitochondrial alterations in microdomains of muscle fibers, plasticity of the mitochondrial reticulum to acute muscle contractions, and advanced age of both sexes.
《我们对进展的看法》强调了骨骼肌线粒体功能中的性别差异，这种差异会随着年龄增长而演变，在高龄时去神经支配的影响会显现出来。差距包括对肌纤维微区中线粒体改变、线粒体网状结构对急性肌肉收缩的可塑性以及两性高龄方面的了解不足。
