运动诱导的骨骼肌纤维类型转变、线粒体生物发生和血管生成的调节。
Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscle.
机构信息
Department of Medicine, University of Virginia, Charlottesville, Virginia, USA.
出版信息
J Appl Physiol (1985). 2011 Jan;110(1):264-74. doi: 10.1152/japplphysiol.00993.2010. Epub 2010 Oct 28.
Abstract
Skeletal muscle exhibits superb plasticity in response to changes in functional demands. Chronic increases of skeletal muscle contractile activity, such as endurance exercise, lead to a variety of physiological and biochemical adaptations in skeletal muscle, including mitochondrial biogenesis, angiogenesis, and fiber type transformation. These adaptive changes are the basis for the improvement of physical performance and other health benefits. This review focuses on recent findings in genetically engineered animal models designed to elucidate the mechanisms and functions of various signal transduction pathways and gene expression programs in exercise-induced skeletal muscle adaptations.
摘要
骨骼肌在响应功能需求变化时表现出极好的可塑性。骨骼肌收缩活动的慢性增加，如耐力运动，导致骨骼肌发生多种生理和生化适应，包括线粒体生物发生、血管生成和纤维类型转变。这些适应性变化是提高身体机能和其他健康益处的基础。本综述重点介绍了基因工程动物模型的最新发现，旨在阐明运动诱导的骨骼肌适应中各种信号转导途径和基因表达程序的机制和功能。
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