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Janus Kinase Inhibitor: A Possible Cause of Hyperammonemic Encephalopathy?

作者信息

Park Jong-Ho, Kim Do-Hyung

机构信息

Department of Neurology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.

出版信息

J Clin Neurol. 2025 May;21(3):247-249. doi: 10.3988/jcn.2025.0039.

DOI:10.3988/jcn.2025.0039
PMID:40308024
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12056130/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df2a/12056130/5f82d3eb72c6/jcn-21-247-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df2a/12056130/5f82d3eb72c6/jcn-21-247-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df2a/12056130/5f82d3eb72c6/jcn-21-247-g001.jpg

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本文引用的文献

1
Hyperammonemic encephalopathy after tyrosine kinase inhibitors: A literature review and a case example.酪氨酸激酶抑制剂治疗后高氨血症性脑病：文献复习及病例举例。
J Oncol Pharm Pract. 2024 Apr;30(3):576-583. doi: 10.1177/10781552231225188. Epub 2024 Jan 22.
2
A Comprehensive Overview of Globally Approved JAK Inhibitors.全球获批的JAK抑制剂综合概述
Pharmaceutics. 2022 May 6;14(5):1001. doi: 10.3390/pharmaceutics14051001.
3
Blocking Jak/STAT signalling using tofacitinib inhibits angiogenesis in experimental arthritis.使用托法替布阻断Jak/STAT信号传导可抑制实验性关节炎中的血管生成。
Arthritis Res Ther. 2021 Aug 14;23(1):213. doi: 10.1186/s13075-021-02587-8.
4
Suggested guidelines for the diagnosis and management of urea cycle disorders: First revision.尿素循环障碍的诊断和管理建议指南：第一版修订。
J Inherit Metab Dis. 2019 Nov;42(6):1192-1230. doi: 10.1002/jimd.12100. Epub 2019 May 15.
5
Multi-Targeted Tyrosine Kinase Inhibitor-Induced Hyperammonemic Encephalopathy: a Report of Two Cases Using Pazopanib, Sunitinib, and Regorafenib.多靶点酪氨酸激酶抑制剂诱发的高氨血症性脑病：两例使用帕唑帕尼、舒尼替尼和瑞戈非尼的病例报告
J Gastrointest Cancer. 2019 Sep;50(3):601-603. doi: 10.1007/s12029-018-0067-6.
6
Hyperammonemia in review: pathophysiology, diagnosis, and treatment.高血氨血症综述：病理生理学、诊断和治疗。
Pediatr Nephrol. 2012 Feb;27(2):207-22. doi: 10.1007/s00467-011-1838-5. Epub 2011 Mar 23.
7
Acute hyperammonemic encephalopathy in adults: imaging findings.成人急性高氨血症性脑病：影像学表现。
AJNR Am J Neuroradiol. 2011 Feb;32(2):413-8. doi: 10.3174/ajnr.A2290. Epub 2010 Nov 18.
8
Acute hepatic encephalopathy: diffusion-weighted and fluid-attenuated inversion recovery findings, and correlation with plasma ammonia level and clinical outcome.急性肝性脑病：弥散加权和液体衰减反转恢复的发现，以及与血浆氨水平和临床结果的相关性。
AJNR Am J Neuroradiol. 2010 Sep;31(8):1471-9. doi: 10.3174/ajnr.A2112. Epub 2010 May 6.
9
Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action?抗血管生成酪氨酸激酶抑制剂：它们的作用机制是什么？
Angiogenesis. 2010 Mar;13(1):1-14. doi: 10.1007/s10456-009-9160-6. Epub 2009 Dec 11.