Department of Gastroenterology, Medical University of Lublin, 20094 Lublin, Poland.
World J Gastroenterol. 2013 Jan 7;19(1):26-34. doi: 10.3748/wjg.v19.i1.26.
Hepatic encephalopathy is a medical phenomenon that is described as a neuropsychiatric manifestation of chronic or acute liver disease that is characterized by psychomotor, intellectual and cognitive abnormalities with emotional/affective and behavioral disturbances. This article focuses on the underlying mechanisms of the condition and the differences between hepatic encephalopathy and noncirrhotic hyperammonemic encephalopathy. Hepatic encephalopathy is a serious condition that can cause neurological death with brain edema and intracranial hypertension. It is assumed that approximately 60%-80% of patients with liver cirrhosis develop hepatic encephalopathy. This review explores the complex mechanisms that lead to hepatic encephalopathy. However, noncirrhotic hyperammonemic encephalopathy is not associated with hepatic diseases and has a completely different etiology. Noncirrhotic hyperammonemic encephalopathy is a severe occurrence that is connected with multiple pathogeneses.
肝性脑病是一种医学现象，被描述为慢性或急性肝病的神经精神表现，其特征是伴有情绪/情感和行为障碍的精神运动、智力和认知异常。本文重点介绍了该病的潜在机制，以及肝性脑病与非肝硬化高氨血症性脑病的区别。肝性脑病是一种严重的疾病，可导致脑水肿和颅内高压引起的神经死亡。据推测，约 60%-80%的肝硬化患者会发生肝性脑病。本综述探讨了导致肝性脑病的复杂机制。然而，非肝硬化高氨血症性脑病与肝脏疾病无关，具有完全不同的病因。非肝硬化高氨血症性脑病是一种严重的疾病，与多种发病机制有关。
