GANT61调节卵巢癌中的自噬和脂质代谢。
GANT61 Modulates Autophagy and Lipid Metabolism in Ovarian Cancer.
作者信息
Pan Yibin, Chen Lingfeng, Shen Jinlu, Hong Shihao, Guan Xiaojing, Ma Xudong, Tang Rongrong, Lu Meifei, Sun Fangying, Shang Shanliang, Dai Yongdong, Zhou Zhaokai, Zhang Songying, Yang Jianhua
机构信息
Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
Zhejiang Provincial Clinical Research Center for Obstetrics and Gynecology, Hangzhou, People's Republic of China.
出版信息
Cell Prolif. 2025 Jul;58(7):e70051. doi: 10.1111/cpr.70051. Epub 2025 May 1.
GANT61 induced autophagy via the AKT pathway and promoted the accumulation of lipid droplets in both cell lines. The molecular mechanism behind this lipid accumulation appears to involve the mediation of SREBP1. Furthermore, the combination of GANT61 with CQ/Fatostatin significantly inhibited the proliferation and clonogenicity of SKOV3 and SKOV3PTX cells.
GANT61通过AKT途径诱导自噬，并促进两种细胞系中脂滴的积累。这种脂质积累背后的分子机制似乎涉及SREBP1的介导。此外，GANT61与CQ/法托司他汀联合使用可显著抑制SKOV3和SKOV3PTX细胞的增殖和克隆形成能力。
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