Gerber C, Hoppeler H, Claassen H, Robotti G, Zehnder R, Jakob R P
J Bone Joint Surg Am. 1985 Sep;67(7):1034-43.
We studied the musculature of the lower extremity in forty-one patients with chronic symptomatic instability of the anterior cruciate ligament. Computed tomographic and clinical measurements of the limb were taken at levels fifteen and twenty-five centimeters proximal to the medial joint line and ten centimeters distal to it. Biopsy specimens from the vastus lateralis of both lower extremities were analyzed by histochemistry and electron microscopy. Computed tomography revealed a decrease in the muscle square area of the affected thigh of 8 per cent as compared with the control lower extremity. There was quadriceps atrophy of 10 per cent and hamstrings atrophy of only 4 per cent. The atrophy of the vastus medialis was significantly greater than that of the entire quadriceps. Histochemistry revealed a similar decrease in fiber size for all fiber types, and hence no shift in fiber type. Electron microscopy showed an increase in intracellular fat but no change in mitochondrial volume density or capillarization.
我们研究了41例患有慢性症状性前交叉韧带不稳定的患者的下肢肌肉组织。在距内侧关节线近端15厘米和25厘米以及远端10厘米处对肢体进行计算机断层扫描和临床测量。对双下肢股外侧肌的活检标本进行组织化学和电子显微镜分析。计算机断层扫描显示，与对照下肢相比，患侧大腿肌肉横截面积减少了8%。股四头肌萎缩10%，而腘绳肌仅萎缩4%。股内侧肌的萎缩明显大于整个股四头肌的萎缩。组织化学显示所有纤维类型的纤维大小都有类似程度的减小，因此纤维类型没有改变。电子显微镜显示细胞内脂肪增加，但线粒体体积密度或毛细血管化没有变化。
