Saleh Gehad Ahmad, Hamdy Omar, Ragab Dina, Farouk Bassante, Allam Mennatalla Mahmoud, Abo Asy Rawan, Denewar Fatmaelzahraa A, Ezat Mohamed
Radiology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Surgical Oncology Department, Oncology Center, Mansoura University, Mansoura, Egypt.
Womens Health Rep (New Rochelle). 2025 Mar 25;6(1):315-324. doi: 10.1089/whr.2024.0153. eCollection 2025.
Ovarian fibrothecoma is a rare benign sex cord-stromal ovarian tumor sorted under the thecoma-fibroma group. We present an analysis of clinical and laboratory findings and the radiological characteristic features of pathologically proven fibrothecomas in variable imaging modalities.
A retrospective analysis was done for 88 patients with 90 pathologically proven ovarian fibrothecoma between January 2011 and December 2023 from our center's prospectively maintained database. All the patients underwent preoperative ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI) scans, clinical examinations, basic laboratory tests, and tumor markers.
The results of Spearman's correlation revealed a statistically significant positive correlation between the largest tumor diameter and serum level. CA 125, the degree of ascites, and diffusion weighted imaging (DWI) signal intensity while the results of point biserial correlation revealed a statistically significant correlation of the largest tumor diameter with the presence of ascites, cystic changes, abdominal enlargement, surgery type, and border type. There were also statistically significantly higher hypoechoic lesions in the smaller tumor group ( = 0.001) but not for isoechoic ( = 0.099) and mixed ( = 0.052). Regarding the MRI, there was a statistically significantly larger tumor diameter in T2 mixed-hyperintense versus hypointense ( = 0.007) and intermediate ( = 0.010) signal intensities.
Fibrothecoma showed a statistically significant positive correlation between the largest tumor diameter with serum level CA 125 and the amount of ascites. On imaging, it shows mild enhancement in both CT and MRI, with a statistically significant positive correlation of the largest tumor diameter with T2 and DWI signal intensity.
卵巢纤维卵泡膜瘤是一种罕见的良性性索间质卵巢肿瘤，归类于卵泡膜瘤 - 纤维瘤组。我们对经病理证实的纤维卵泡膜瘤在多种成像方式下的临床、实验室检查结果及放射学特征进行了分析。
对2011年1月至2023年12月期间来自本中心前瞻性维护数据库的88例患者的90个经病理证实的卵巢纤维卵泡膜瘤进行回顾性分析。所有患者均接受了术前超声、计算机断层扫描（CT）和磁共振成像（MRI）扫描、临床检查、基础实验室检查及肿瘤标志物检查。
Spearman相关性分析结果显示，最大肿瘤直径与血清CA 125水平、腹水程度及扩散加权成像（DWI）信号强度之间存在统计学显著正相关；点二列相关性分析结果显示，最大肿瘤直径与腹水的存在、囊性改变、腹部增大、手术类型及边界类型之间存在统计学显著相关性。较小肿瘤组的低回声病变在统计学上也显著更多（P = 0.001），但等回声（P = 0.099）和混合回声（P = 0.052）情况并非如此。关于MRI，T2加权像上混合高信号与低信号（P = 0.007）及中等信号（P = 0.010）强度相比，肿瘤直径在统计学上显著更大。
纤维卵泡膜瘤最大肿瘤直径与血清CA 125水平及腹水量之间存在统计学显著正相关。在影像学上，它在CT和MRI上均表现为轻度强化，最大肿瘤直径与T2加权像及DWI信号强度之间存在统计学显著正相关。
