Du Wenxin, Hou Ruxia, Li Xixi, Liu Jiajia, Yang Tingting, Li Junming, Liu Junyu, Wang Xiangyu
Department of Pediatric and Preventive Dentistry, School and Hospital of Stomatology, Shanxi Medical University, Taiyuan, China.
Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, China.
Front Public Health. 2025 Apr 16;13:1559384. doi: 10.3389/fpubh.2025.1559384. eCollection 2025.
With the development of society, ecological and environmental problems have gradually become the focus of attention of countries around the world, among which environmental particulate matter poses a major harm to health. This article elucidates the association between environmental particulate matter and dental caries and provides new insights into the underlying mechanisms. In addition, this study emphasizes the role of oxidative stress in the occurrence and development of dental caries, and a new research pathway based on the interaction between oxidative stress and dental caries based on the Nrf2 pathway has become the focus of future research on the pathogenesis of dental caries. The relevant content of this review can provide a certain theoretical basis for the follow-up multidisciplinary joint research of researchers, and provide a certain reference for public health personnel and policymakers to formulate prevention strategies and public health interventions, carry out more accurate individualized treatment for high-risk groups, implement key prevention and treatment, and promote the overall improvement of effective prevention and treatment of caries. Ultimately, more attention must be paid to addressing the relationship between environmental particulate pollution and dental caries, with a focus on pollution control and reducing preventable environmental risks in order to protect oral health more broadly.
随着社会的发展,生态与环境问题逐渐成为世界各国关注的焦点,其中环境颗粒物对健康构成重大危害。本文阐述了环境颗粒物与龋齿之间的关联,并为其潜在机制提供了新的见解。此外,本研究强调了氧化应激在龋齿发生发展中的作用,基于Nrf2途径的氧化应激与龋齿相互作用的新研究途径已成为未来龋齿发病机制研究的重点。本综述的相关内容可为研究人员后续的多学科联合研究提供一定的理论依据,为公共卫生人员和政策制定者制定预防策略和公共卫生干预措施、对高危人群进行更精准的个体化治疗、实施重点防治以及推动龋齿有效防治的整体提升提供一定参考。最终,必须更加关注解决环境颗粒物污染与龋齿之间的关系,重点是控制污染和降低可预防的环境风险,以便更广泛地保护口腔健康。