Telkkälä Anni, Sinikumpu Suvi-Päivikki, Huilaja Laura
Department of Dermatology University Hospital of Oulu, Oulu, Finland and Medical Research Center, Research Unit of Clinical Medicine, University of Oulu Oulu Finland.
Health Sci Rep. 2025 Apr 30;8(5):e70697. doi: 10.1002/hsr2.70697. eCollection 2025 May.
Acne vulgaris is a common inflammatory disease of the skin. Acne occurring in > 25 years old is called "adult acne," and it occurs more commonly in women than in men.
The aim of this study was to examine the recent findings of the connection between genetic factors, hormones and diet with adult female acne.
The study was conducted as a systematic literature review. For the review, data searches were made on the PubMed and Scopus databases. Finally, 20 articles met the inclusion criteria.
According to this systematic literature review, several different hormones may be linked to the development of adult acne. Androgens play a particularly important role, as they can stimulate growth of the sebaceous glands and increase the secretion of sebum, thus promoting the formation of skin changes associated with acne. A high glycemic diet increases the secretion of insulin, which in turn causes an increase in the amount of insulin-like growth factor (IGF)-1. IGF-1 increases the growth of the sebaceous gland, sebum production, keratinocyte proliferation and it activates androgen synthesis, thus contributing to acne pathogenesis. Adults with acne have a positive familial history more often than healthy controls, which indicates the genetic nature of adult acne.
This literature review highlighted that especially hyperandrogenism, a positive familial history and a high-glycemic diet may be linked to the development of adult acne. Understanding the pathogenesis of adult acne is crucial for effective treatment.
寻常痤疮是一种常见的皮肤炎症性疾病。25岁以上出现的痤疮被称为“成人痤疮”，女性比男性更常见。
本研究的目的是探讨遗传因素、激素和饮食与成年女性痤疮之间联系的最新研究结果。
本研究作为一项系统的文献综述进行。为进行综述，在PubMed和Scopus数据库上进行了数据检索。最后，20篇文章符合纳入标准。
根据这项系统的文献综述，几种不同的激素可能与成人痤疮的发生有关。雄激素起着特别重要的作用，因为它们可以刺激皮脂腺生长并增加皮脂分泌，从而促进与痤疮相关的皮肤变化的形成。高糖饮食会增加胰岛素分泌，进而导致胰岛素样生长因子（IGF）-1量的增加。IGF-1会增加皮脂腺生长、皮脂产生、角质形成细胞增殖，并激活雄激素合成，从而导致痤疮发病。患有痤疮的成年人比健康对照者更常具有阳性家族史，这表明成人痤疮的遗传性质。
这篇文献综述强调，特别是高雄激素血症、阳性家族史和高糖饮食可能与成人痤疮的发生有关。了解成人痤疮的发病机制对于有效治疗至关重要。
