Negahban Hossein, Heidari Nazila, Heidari Amirhossein, Ghane Yekta, Shirkhoda Mohammad, Jalaeefar Amirmohsen
Cancer Research Center of Cancer institute Tehran University of Medical Sciences Tehran Iran.
School of Medicine Iran University of Medical Sciences Tehran Iran.
Health Sci Rep. 2025 Apr 30;8(5):e70710. doi: 10.1002/hsr2.70710. eCollection 2025 May.
Anaplastic thyroid carcinoma (ATC) is a rare type of malignancy ranking among the most aggressive diseases globally, with an extremely poor prognosis. No optimal standardized treatment has been established yet to promote ATC's prognosis and increase the patients' median survival. We aim to assess the effectiveness of surgery alone or combined with other treatment approaches for ATC patients.
PubMed, Web of Science, and Scopus databases were systematically searched until June 1st, 2023. Study selection was limited to English retrospective studies. A citation search was also performed for the final articles that were included. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for systematic reviews and meta-analyses.
During our search, we came to include 56 articles containing 16,246 patients suffering from ATC. We assessed the overall survival by treatment method and stage, emphasizing surgery's role. The most common efficacious treatment option in patients with resectable cancer is a combination of surgery with adjuvant chemoradiotherapy. However, surgery for stage IVC patients is controversial. Additionally, surgery and multimodality treatment can be affected by patients' characteristics, such as tumor size.
Stage IVA and IVB resectable cancers may benefit from the combination of surgery and adjuvant therapies. However, the effectiveness of invasive treatments and the selection of appropriate adjuvant therapy options for IVC-stage patients are still controversial.
间变性甲状腺癌（ATC）是一种罕见的恶性肿瘤，在全球最具侵袭性的疾病中名列前茅，预后极差。目前尚未建立优化的标准化治疗方法来改善ATC的预后并提高患者的中位生存期。我们旨在评估单纯手术或联合其他治疗方法对ATC患者的有效性。
系统检索了截至2023年6月1日的PubMed、科学网和Scopus数据库。研究选择限于英文回顾性研究。还对纳入的最终文章进行了引文检索。本研究遵循系统评价和Meta分析的首选报告项目（PRISMA）指南进行系统评价和Meta分析。
在检索过程中，我们纳入了56篇文章，其中包含16246例ATC患者。我们根据治疗方法和分期评估总生存期，重点关注手术的作用。可切除癌症患者最常见的有效治疗选择是手术联合辅助放化疗。然而，IVC期患者的手术存在争议。此外，手术和多模式治疗可能会受到患者特征（如肿瘤大小）的影响。
IVA期和IVB期可切除癌症可能受益于手术与辅助治疗的联合。然而，侵入性治疗的有效性以及为IVC期患者选择合适的辅助治疗方案仍存在争议。
